ArticleYonsei medical journal2017
Filaggrin Mutation in Korean Patients with Atopic Dermatitis.
Article in Yonsei medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Pooled it
- Epithelial Barrier Dysfunction in Atopic Dermatitis, Allergic Contact Dermatitis, and Chronic Spontaneous Urticaria and its Therapeutic Implications.Current allergy and asthma reports · 2026Review
- Understanding worldwide skin atopy across regions. Environmental, cultural, genetic, and lifestyle factors.Frontiers in medicine · 2026Review
- Unraveling the Pathogenesis of Asian Atopic Dermatitis: Key Characteristics and Insights.Annals of dermatology · 2025Review
- Relevance of Coding Variation inJID innovations : skin science from molecules to population health · 2023Article
- Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study.Biomedicines · 2022Article
- Dietary Diversity during Early Infancy Increases Microbial Diversity and Prevents Egg Allergy in High-Risk Infants.Immune network · 2022Article
- Update on the Pathogenesis and Therapy of Atopic Dermatitis.Clinical reviews in allergy & immunology · 2021Review
- Dupilumab Therapy Improves Stratum Corneum Hydration and Skin Dysbiosis in Patients With Atopic Dermatitis.Allergy, asthma & immunology research · 2021Article
- FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model and human samples.EBioMedicine · 2020Article
- Epidemiology, Diagnosis, and Treatment of Atopic Dermatitis in the Developing Countries of Asia, Africa, Latin America, and the Middle East: A Review.Dermatology and therapy · 2019Review
- Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.Allergy · 2019Article
- Clinical Characteristics and Genetic Variations in Early-Onset Atopic Dermatitis Patients.Annals of dermatology · 2019Article
- Filaggrin Gene Mutation in Pediatric Patients with Atopic Dermatitis: A Look into Indian Gene Pool, a Pilot Study.Indian journal of dermatologyArticle
- Targeted Filaggrin Gene (Indian dermatology online journalArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAtopic dermatitis (AD) is a chronic, relapsing eczematous inflammatory skin disease. Mutations in the filaggrin gene (FLG) are major predisposing factors for AD. Ethnic differences exist between Asian and European populations in the frequency and spectrum of FLG mutations. Moreover, a distinct set of FLG mutations has been reported in Asian populations. The aim of this study was to examine the spectrum of FLG mutations in Koreans with AD. We also investigated the association of FLG mutations and clinical features of AD and compared the Korean FLG landscape with that of other East Asian countries. MATERIALS AND
methodsSeventy Korean patients with AD were enrolled in this study. Fourteen FLG mutations previously detected in Korean, Japanese, and Chinese patients were screened by genotyping.
resultsFour FLG null mutations (3321delA, K4022X, S3296X, and S2889X) were identified in eleven patients (15.7%). The most commonly detected mutations in Korean patients with AD were 3321delA (n=6, 9.1%) and K4022X (n=3, 4.5%). FLG mutations were significantly associated with elevated IgE (≥200 KIU/L and/or MAST-CLA >3+, p=0.005), palmar hyperlinearity (p<0.001), and a family history of allergic disease (p=0.021).
conclusionThis study expanded our understanding of the landscape of FLG mutations in Koreans and revealed an association between FLG mutations and AD phenotype.
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