ArticleYonsei medical journal2017
Impact of Serum Leptin to Adiponectin Ratio on Regression of Metabolic Syndrome in High-Risk Individuals: The ARIRANG Study.
Article in Yonsei medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 25 citations in OpenAlex.
- Adipokines and Transitions in Metabolic Health Over Time: The Atherosclerosis Risk In Communities (ARIC) Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Linking serum leptin and TSH among metabolic syndrome patients with and without hypothyroidism.Bioinformation · 2025Article
- The Association Between Adiponectin Gene Polymorphism (rs1501299) and Metabolic Syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Adipokines and Gamma-Glutamyl Transferase as Biomarkers of Metabolic Syndrome Risk in Mexican School-Aged Children.Nutrients · 2024Article
- Association of rs2241766 and rs1501299 polymorphisms in the adiponectin gene with metabolic syndrome.Immunity, inflammation and disease · 2024Article
- The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity.Journal of education and health promotion · 2024Article
- Adiponectin and leptin levels of patients after sleeve gastrectomy, Roux-en-Y gastric bypass, and single anastomosis sleeve ileal bypass surgeries.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Prospective Association of Circulating Adipokines with Cardiometabolic Risk Profile Among Women: The Rape Impact Cohort Evaluation Study.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Relationship between Adipose Tissue Derived Hormones and Cardiometabolic Risk according to Obesity Status.Clinical nutrition research · 2021Article
- Effect of left or right gastric artery interventional embolization on obesity and ghrelin/leptin expression in pigs.American journal of translational research · 2021Article
- Prospective Associations of Serum Adiponectin, Leptin, and Leptin-Adiponectin Ratio with Incidence of Metabolic Syndrome: The Korean Genome and Epidemiology Study.International journal of environmental research and public health · 2020Article
- Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment.Nutrients · 2020Review
- In Reply to Gürdoğan and AltayBalkan medical journal · 2019Article
- In Regard to Otelea et al.Balkan medical journal · 2019Article
- The Adipokine Profile and the Cardiometabolic Risk in Non-Obese Young AdultsBalkan medical journal · 2019Article
- Leptin-adiponectin imbalance as a marker of metabolic syndrome among Chinese children and adolescents: The BCAMS study.PloS one · 2017Article
- Adipokine Contribution to the Pathogenesis of Osteoarthritis.Mediators of inflammation · 2017Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe ratio of serum leptin to adiponectin (L/A ratio) could be used as a marker for insulin resistance. However, few prospective studies have investigated the impact of L/A ratio on improvement of metabolic components in high-risk individuals with metabolic syndrome. We examined the association between L/A ratio and the regression of metabolic syndrome in a population-based longitudinal study. MATERIALS AND
methodsA total of 1017 subjects (431 men and 586 women) with metabolic syndrome at baseline (2005-2008) were examined and followed (2008-2011). Baseline serum levels of leptin and adiponectin were analyzed by radioimmunoassay. Area under the receiver operating characteristics curve (AUROC) analyses were used to assess the predictive ability of L/A ratio for the regression of metabolic syndrome.
resultsDuring an average of 2.8 years of follow-up, metabolic syndrome disappeared in 142 men (32.9%) and 196 women (33.4%). After multivariable adjustment, the odds ratios (95% confidence interval) for regression of metabolic syndrome in comparisons of the lowest to the highest tertiles of L/A ratio were 1.84 (1.02-3.31) in men and 2.32 (1.37-3.91) in women. In AUROC analyses, L/A ratio had a greater predictive power than serum adiponectin for the regression of metabolic syndrome in both men (p=0.024) and women (p=0.019).
conclusionLow L/A ratio is a predictor for the regression of metabolic syndrome. The L/A ratio could be a useful clinical marker for management of high-risk individuals with metabolic syndrome.
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