Evidence map›Paper›PMID 28120562›Full record

ArticleYonsei medical journal2017

Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects.

Dae Young Cheon, Jun Goo Kang, Seong Jin Lee, Sung Hee Ihm, Eun Jig Lee, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim

Abstract read
In one paragraph

Article in Yonsei medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  19. IRISIN AND CHEMERIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.Acta endocrinologica (Bucharest, Romania : 2005)
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dae Young CheonDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Jun Goo KangDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Seong Jin LeeDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Sung Hee IhmDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Eun Jig LeeDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Moon Gi ChoiDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Hyung Joon YooDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Chul Sik KimDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea. ironeat@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChemerin has been suggested to be linked to insulin resistance and type 2 diabetes mellitus (T2DM). However, the relationship between visceral adiposity and chemerin levels remains unclear in subjects with T2DM. In this study, we investigated the relationship between serum chemerin levels and visceral adiposity. MATERIALS AND

methodsThis study included 102 subjects newly diagnosed with T2DM. The relationships between serum chemerin levels and clinical and biochemical parameters were examined. Multiple linear regression analysis was performed to determine the predictable factors of serum chemerin levels.

resultsSerum chemerin levels showed significant positive correlations with body mass index (BMI), waist circumference (WC), visceral fat thickness (VFT), insulin levels, the homeostasis model assessment of insulin resistance, and levels of triglycerides (log-transformed) and high-sensitivity C-reactive protein, while showing significant negative correlations with high-density lipoprotein cholesterol. After adjusting for BMI and WC, VFT showed a significant relationship with serum chemerin levels (r=0.222, p=0.027). Moreover, VFT was an independent predictive factor of serum chemerin levels (β=0.242, p=0.041).

conclusionWe demonstrated that chemerin is linked to metabolic syndrome components. Moreover, serum chemerin levels were associated significantly with obesity, especially visceral adipose tissue, in subjects with T2DM.

Indexed as

Intra-Abdominal FatWaist CircumferenceAdiposityAdultBiomarkersBody Mass IndexChemokinesCholesterol, HDLC-Reactive ProteinDiabetes Mellitus, Type 2FemaleHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsMaleMetabolic SyndromeBiomarkersChemokinesCholesterol, HDLC-Reactive ProteinIntercellular Signaling Peptides and ProteinsRARRES2 protein, humanTriglyceridesChemerintype 2 diabetes mellitusvisceral fat

Identifiers

PMID28120562
PMCPMC5290011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.