ArticleMuscle & nerve2017
Median and ulnar nerve injuries reduce volitional forelimb strength in rats.
Article in Muscle & nerve, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- The tactile experience paired with vagus nerve stimulation determines the degree of sensory recovery after chronic nerve damage.Behavioural brain research · 2021Article
- Vagus Nerve Stimulation Paired With Rehabilitative Training Enhances Motor Recovery After Bilateral Spinal Cord Injury to Cervical Forelimb Motor Pools.Neurorehabilitation and neural repair · 2020Article
- Restoration of Somatosensory Function by Pairing Vagus Nerve Stimulation with Tactile Rehabilitation.Annals of neurology · 2020Article
- Enhancing plasticity in central networks improves motor and sensory recovery after nerve damage.Nature communications · 2019Article
- Quantitative assessment of cortical somatosensory digit representations after median and ulnar nerve injury in rats.Experimental brain research · 2019Article
- The Median Nerve Injury Model in Pre-clinical Research - A Critical Review on Benefits and Limitations.Frontiers in cellular neuroscience · 2019Review
- Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury.eLife · 2018Article
- Vagus Nerve Stimulation Enhances Stable Plasticity and Generalization of Stroke Recovery.Stroke · 2018Article
- Radial nerve injury causes long-lasting forelimb sensory impairment and motor dysfunction in rats.Pain reportsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPeripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function after PNI.
methodsWe developed an automated behavioral assay that provides quantitative measurements of volitional forelimb strength in rats. Multiple forelimb PNI models involving the median and ulnar nerves were used to assess forelimb function for up to 13 weeks postinjury.
resultsDespite multiple weeks of task-oriented training following injury, rats exhibit significant reductions in multiple quantitative parameters of forelimb function, including maximal pull force and speed of force generation. DISCUSSION: This study demonstrates that the isometric pull task is an effective method of evaluating forelimb function following PNI and may aid in development of therapeutic interventions to restore function. Muscle Nerve 56: 1149-1154, 2017.
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Registered trials
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