ArticleInternational journal of cancer2017
Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study.
Article in International journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Nature communications · 2021Pooled it
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- Alcohol consumption and cancer progression: Mechanistic insights, immune dysregulation, and public health implications.Translational oncology · 2026Review
- Association between body-mass index change and lung cancer risk in Korea: nested case-control study.BMC cancer · 2025Observational
- Light to Moderate Alcohol Consumption and Cancer Incidence: The Norwegian Women and Health Cohort Study.Clinical epidemiology · 2025Article
- Risk of Lung Cancer and Risk Factors of Lung Cancer in People Infected with Tuberculosis.Journal of cancer prevention · 2024Article
- Cancer incidence following non-neoplastic medical conditions: a prospective population-based cohort study.Acta oncologica (Stockholm, Sweden) · 2024Article
- Geographical Disparities in Lung Cancer in Canada: A Review.Current oncology reports · 2024Review
- Assessment of the Association of Chlamydia e pneumoniae Infection with Lung Cancer in a Moroccan Patients' Cohort.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Associations between diet and incidence risk of lung cancer: A Mendelian randomization study.Frontiers in nutrition · 2023Article
- The effects of modest drinking on life expectancy and mortality risks: a population-based cohort study.Scientific reports · 2022Article
- Article
- Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study.Annals of translational medicine · 2021Article
- The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.Lung cancer (Amsterdam, Netherlands) · 2021Article
- A prediction model to evaluate the pretest risk of malignancy in solitary pulmonary nodules: evidence from a large Chinese southwestern population.Journal of cancer research and clinical oncology · 2021Article
- Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis.PloS one · 2020Observational
- Research on lung cancer and its funding, 2004-2018.Ecancermedicalscience · 2020Article
- Functional validity, role, and implications of heavy alcohol consumption genetic loci.Science advances · 2020Article
- Body Mass Index (BMI), BMI Change, and Overall Survival in Patients With SCLC and NSCLC: A Pooled Analysis of the International Lung Cancer Consortium.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Article
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Authors and funding
56 authors.
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Abstract
It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.
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