Evidence map›Paper›PMID 28120325›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2017

Predictive factors for survival in neoadjuvant radiochemotherapy for advanced rectal cancer.

A Reig Castillejo, I Membrive, P Foro, J Quera, X Sanz, N Rodriguez, E Fernández-Velilla, O Pera, A Ortiz, M Algara

Abstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A Reig CastillejoDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain. areig@parcdesalutmar.cat.ORCID http://orcid.org/0000-0003-3691-9679
I MembriveDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
P ForoDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
J QueraDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
X SanzDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
N RodriguezDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
E Fernández-VelillaDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
O PeraDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
A OrtizDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.
M AlgaraDepartment of Radiation and Oncology, Hospital de l'Esperança, Parc de Salut Mar, C/Sant Josep de la Muntanya, 12, 08024, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeoadjuvant radiochemotherapy followed by radical surgery is the standard approach in advanced rectal carcinoma. Tumor response is determined in histological specimen.

objectiveTo assess predictive factors for survival in 115 patients. PATIENTS AND

method115 patients treated with neoadjuvant radiochemotherapy followed by radical surgery with total mesorectal excision, in our hospital from January 2007 to December 2014. All patients received pelvic radiotherapy with concomitant chemotherapy, followed by radical surgery and in some adjuvant chemotherapy.

resultsIn univariate analysis, distance to anal verge, radial margin, perineural invasion, and good grade regression are predictive factors for both, specific and disease free survival; and in multivariant, only radial margin and perineural invasion were predictive factors for survival. We found distance to anal verge (<5 cm) as the only clinical factor to predict a positive margin in the histologic specimen.

conclusionsPerineural invasion and positive radial margin are predictive factors for both specific and disease free survival.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overChemoradiotherapy, AdjuvantFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoadjuvant TherapyPrognosisRectal NeoplasmsRetrospective StudiesSurvival RateOverall survivalPredictive factorsRadiochemotherapyRectal carcinoma

Identifiers

PMID28120325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.