ReviewCurrent atherosclerosis reports2017
Evaluating Periodontal Treatment to Prevent Cardiovascular Disease: Challenges and Possible Solutions.
Review in Current atherosclerosis reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Does Nonsurgical Periodontal Treatment Improve Systemic Health?Journal of dental research · 2021Pooled it
- Periodontal disease and cardiovascular events: mechanisms, biomarkers, and clinical translation.NPJ cardiovascular health · 2026Review
- Identification of core genes related to exosomes and screening of potential targets in periodontitis using transcriptome profiling at the single-cell level.BMC oral health · 2025Article
- MiR-146a participates in regulating the progression of periodontitis through the Wnt/β-catenin signaling pathway.PloS one · 2025Article
- Article
- More than just teeth: How oral health can affect the heart.American heart journal plus : cardiology research and practice · 2024Review
- Impact of Periodontitis on Endothelial Risk Dysfunction and Oxidative Stress Improvement in Patients with Cardiovascular Disease.Journal of clinical medicine · 2024Review
- Circ_0099630 knockdown alleviates lipopolysaccharide-induced injuries of human periodontal ligament cells through the inhibition of TLR4 by releasing miR-409-3p.BMC oral health · 2023Article
- Health promotion through structured oral hygiene and good tooth alignment.GMS hygiene and infection control · 2022Review
- Grand challenges in oral health and nutrition: We are what we eat.Frontiers in oral health · 2022Article
- The human oral virome: Shedding light on the dark matter.Periodontology 2000 · 2021Review
- Panoramic Dental Reconstruction for Faster Detection of Dental Pathology on Medical Non-dental CT Scans: a Proof of Concept from CT Neck Soft Tissue.Journal of digital imaging · 2021Article
- The Association Between Periodontitis and Cardiovascular Disease: an Update.Current atherosclerosis reports · 2020Review
- Serum IgG Antibodies against Periodontal Microbes and Cancer Mortality.JDR clinical and translational research · 2020Article
- Periodontal Antibodies and All-Cause and Cardiovascular Disease Mortality.Journal of dental research · 2020Article
- Detection of Dental Pathologies in Routine Paranasal CT Scans: A Retrospective Study.Journal of clinical and diagnostic research : JCDR · 2017Article
- Assessment of knowledge, awareness, and attitude among patients with cardiovascular disease about its association with chronic periodontitis.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewPeriodontal disease is correlated with cardiovascular disease (CVD) in observational studies, but a causal connection has not been established. The empirical evidence linking periodontal disease and CVD consists of a large body of observational and mechanistic studies, but a limited number of clinical trials evaluating the effects of periodontal treatment on surrogate CVD endpoints. RECENT
findingsNo randomized controlled trial has been conducted to evaluate the effect of periodontal treatment on CVD risk. In this review, we have summarized these data, described possible biological mechanisms linking periodontal disease and CVD, discussed barriers to conducting a randomized controlled trial to evaluate this hypothesis, and provided an alternative analytical approach using causal inference methods to answer the question. The public health implications of addressing this question can be significant because periodontal disease is under-treated, and highly prevalent among adults at risk of CVD. Even a small beneficial effect of periodontal treatment on CVD risk can be important.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.