Evidence map›Paper›PMID 28120301›Full record

ArticleJournal of neuro-oncology2017

Clinical efficacy and safety of surface imaging guided radiosurgery (SIG-RS) in the treatment of benign skull base tumors.

Steven K M Lau, Kunal Patel, Teddy Kim, Erik Knipprath, Gwe-Ya Kim, Laura I Cerviño, Joshua D Lawson, Kevin T Murphy, Parag Sanghvi, Bob S Carter and 1 more

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Recent advanced in Surface Guided Radiation Therapy.Radiation oncology (London, England) · 2020
    Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Steven K M LauDepartment of Radiation Oncology, University of Texas Southwestern, Dallas, TX, USA.
Kunal PatelCenter for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
Teddy KimCenter for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
Erik KnipprathCenter for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
Gwe-Ya KimDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Laura I CerviñoDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Joshua D LawsonDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Kevin T MurphyDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Parag SanghviDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Bob S CarterCenter for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
Clark C ChenCenter for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA. clarkchen@ucsd.edu.
University of California, San Diego · USCenter for Theoretical Biological Physics · USMoores Cancer CenterThe University of Texas Southwestern Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
NIGMS NIH HHS T32 GM007198
6 · The paper itself

Abstract

Frameless, surface imaging guided radiosurgery (SIG-RS) is a novel platform for stereotactic radiosurgery (SRS) wherein patient positioning is monitored in real-time through infra-red camera tracking of facial topography. Here we describe our initial clinical experience with SIG-RS for the treatment of benign neoplasms of the skull base. We identified 48 patients with benign skull base tumors consecutively treated with SIG-RS at a single institution between 2009 and 2011. Patients were diagnosed with meningioma (n = 22), vestibular schwannoma (n = 20), or nonfunctional pituitary adenoma (n = 6). Local control and treatment-related toxicity were retrospectively assessed. Median follow-up was 65 months (range 61-72 months). Prescription doses were 12-13 Gy in a single fraction (n = 18), 8 Gy × 3 fractions (n = 6), and 5 Gy × 5 fractions (n = 24). Actuarial tumor control rate at 5 years was 98%. No grade ≥3 treatment-related toxicity was observed. Grade ≤2 toxicity was associated with symptomatic lesions (p = 0.049) and single fraction treatment (p = 0.005). SIG-RS for benign skull base tumors produces clinical outcomes comparable to conventional frame-based SRS techniques while enhancing patient comfort.

Indexed as

AdultAgedAged, 80 and overFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedRadiosurgeryRetrospective StudiesSkull Base NeoplasmsTomography, X-Ray ComputedBenign skull base tumorFrameless radiosurgeryImage guided radiosurgerySIG-RSStereotactic radiosurgerySurface imaging guided radiosurgery

Identifiers

PMID28120301
OpenAlexW2581084705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.