ArticleMolecular diagnosis & therapy2017
Analysis of rs8067378 Polymorphism in the Risk of Uterine Cervical Cancer from a Polish Population and its Impact on Gasdermin B Expression.
Article in Molecular diagnosis & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Association BetweenFrontiers in genetics · 2022Pooled it
- Integrated bioinformatics analyses for GSDMB in carcinogenesis and progression of bladder cancer.Translational andrology and urology · 2026Article
- Review
- GSDMB: A novel, independent prognostic marker and potential new therapeutic target in clear cell renal cell carcinoma.Oncology letters · 2024Article
- New prospects of cancer therapy based on pyroptosis and pyroptosis inducers.Apoptosis : an international journal on programmed cell death · 2024Review
- Role of gasdermin family proteins in cancers (Review).International journal of oncology · 2023Review
- Immune-pyroptosis-related genes predict the prognosis of kidney renal clear cell carcinoma.Translational oncology · 2023Article
- Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.Cell death and differentiation · 2023Article
- Regulation of gasdermins in pyroptosis and cytokine release.Advances in immunology · 2023Article
- Pyroptosis-related genesFrontiers in genetics · 2023Article
- Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma.Heliyon · 2022Review
- GSDMs are potential therapeutic targets and prognostic biomarkers in clear cell renal cell carcinoma.Aging · 2022Article
- Construction of Pyroptosis-Related Prognostic and Immune Infiltration Signature in Bladder Cancer.Disease markers · 2022Article
- Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria.Frontiers in public health · 2022Article
- Gasdermin-B Pro-Tumor Function in Novel Knock-in Mouse Models Depends on theFrontiers in cell and developmental biology · 2022Article
- Article
- Identification and validation of a pyroptosis-related prognostic signature for thyroid cancer.Cancer cell international · 2021Article
- Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.American journal of respiratory and critical care medicine · 2021Article
- Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis.Journal of immunology research · 2021Article
- High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer.BioMed research international · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe studied the role of the NC_000017.10:g.38051348A>G (rs8067378) single nucleotide polymorphism (SNP) located 9.5 kb downstream of gasdermin B (GSDMB), in the development and progression of cervical squamous cell carcinomas (SCC).
methodsUsing high-resolution melting curve analysis, we genotyped this SNP in patients with cervical SCC (n = 486) and controls (n = 511) from the Polish Caucasian population. Logistic regression analysis was used to adjust for the effect of confounders such as age, parity, oral contraceptive use, tobacco smoking, and menopausal status. The effect of this SNP on the expression of GSDMB was studied by reverse transcription and quantitative real-time polymerase chain reaction analysis of GSDMB transcript levels in SCC tissues.
resultsFor all patients with SCC, the p trend value calculated for rs8067378 was statistically significant (p
conclusionsThe rs8067378 SNP variants may increase the expression of GSDMB and the risk of the development and progression of cervical SCC.
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