Evidence map›Paper›PMID 28120232›Full record

ReviewProgress in the chemistry of organic natural products

Molecular Targets of the Phytocannabinoids: A Complex Picture.

Paula Morales, Dow P Hurst, Patricia H Reggio

Abstract readReview
In one paragraph

Review in Progress in the chemistry of organic natural products. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 250 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Cys-loop receptors on cannabinoids: All high?Frontiers in physiology · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Effects and safety of a CBD-richFrontiers in pharmacology · 2025
    Trial
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Cannabidiol-Ion Channel Interactions Represent a Promising Preventive and Therapeutic Strategy in Hepatocellular Carcinoma.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  18. Review
  19. ComparativeFrontiers in toxicology · 2026
    Article
  20. Observational

190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paula MoralesChemistry and Biochemistry Department, UNC Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA.
Dow P HurstChemistry and Biochemistry Department, UNC Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA.
Patricia H ReggioChemistry and Biochemistry Department, UNC Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA. phreggio@uncg.edu.

Funding

Molecular Determinants of Cannabinoid ActivityR01DA003934 · NIDA · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI REGGIO, PATRICIA HODAPP · 1985 to 2019
$5.6M
Senior Scientist Award: Molecular Determinants for Cannabinoid ActivityK05DA021358 · NIDA · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI REGGIO, PATRICIA HODAPP · 2007 to 2016
$1.3M
NIDA NIH HHS K05 DA021358NIDA NIH HHS R01 DA003934
6 · The paper itself

Abstract

For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. These effects are associated with the phytocannabinoids which are oxygen containing C

Indexed as

AnimalsCannabinoidsCannabisReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2CannabinoidsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2CB1 receptorCB2 receptorCBCCBDCBDVCBECBGCBLCBNCBNDCBTCBVGlycine receptorGPCRPhytocannabinoidPPARγTHCVTRPA1 channelTRPM8 channelTRPV1 channelΔ8-THCΔ9-THC

Identifiers

PMID28120232
PMCPMC5345356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.