Evidence map›Paper›PMID 28120208›Full record

ArticleChinese journal of integrative medicine2017

Huannao Yicong Formula () regulates γ-secretase activity through APH-1 and PEN-2 gene ragulation pathways in hippocampus of APP/PS1 double transgenic mice.

Zhi-Yong Wang, Jian-Gang Liu, Yun Wei, Mei-Xia Liu, Qi Wang, Lin Liang, Hui-Min Yang, Hao Li

Abstract read
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In one paragraph

Article in Chinese journal of integrative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Journal of ginseng research · 2023
    Review
  3. The Chinese herbal formulaNeuropsychiatric disease and treatment · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhi-Yong WangGeriatric Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Jian-Gang LiuDepartment of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Yun WeiGeriatric Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Mei-Xia LiuGeriatric Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Qi WangGeriatric Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Lin LiangGeriatric Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Hui-Min YangGeriatric Department, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.
Hao LiGeriatric Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. xyhplihao1965@126.com.
Xiyuan Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the effects of Huannao Yicong Formula (, HYF) on learning and memory and it's regulating effect on γ-secretase related anterior pharynx defective 1 (APH-1), presenilin enhancer-2 (PEN-2) signaling pathway, so as to discuss and further clarify the mechanism of HYF on Alzheimer's disease.

methodsSixty APP/PS1 transgenic mice, randomly allocated into 4 groups, the model group, the donepezil group (0.65 mg/kg), HYF low-dose group (HYF-L, 5.46 g/kg) and HYF high-dose group (HYF-H, 10.92 g/kg), 15 for each group. Another 15 C57BL/6J mice with the same age and same genetic background were allocated into the control group, proper dosage of drugs or distilled water were given by intragastric administration once daily for 12 weeks. After 12 weeks of administration, the learning and memory abilities of mice in each group was evaluated by the morris water maze test, amyloid precursor protein (APP), Aβ

resultsHYF can ameliorate learning and memory deficits in APP/PS1 transgenic mice by decreasing the escape latency, improving the number of platform crossing and swimming speed (P<0.01, P<0.05). HYF can decrease the levels of APP, Aβ

conclusionHYF can improve the learning and memory ability by inhibiting the activity of γ-secretase through the CREB/PEN-2 signaling pathway, and this may be one of the therapeutic mechanisms of HYF in Alzheimer's disease.

Indexed as

Amyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsCyclic AMP Response Element-Binding ProteinDrugs, Chinese HerbalEndopeptidasesEnzyme-Linked Immunosorbent AssayFemaleGene Expression RegulationHippocampusHypoxia-Inducible Factor 1, alpha SubunitImmunohistochemistryLearningMaleMembrane ProteinsMemory DisordersAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAph1a protein, mouseCyclic AMP Response Element-Binding ProteinDrugs, Chinese HerbalEndopeptidasesHif1a protein, mousehuannao yicongHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsPresenilin-1Presenilin-2RNA, MessengerAlzheimer’s diseaseHuannao Yicong Formulaβ-amyloidγ-secretase

Identifiers

PMID28120208
OpenAlexW2580658908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.