ArticleWorld journal of surgery2017
Role of Postoperative C-Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer.
Article in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Prognostic Role of Postoperative Inflammation After Minimally Invasive Resection for Colorectal Cancer.Annals of surgical oncology · 2026Article
- Prognostic significance of postoperative serum C-reactive protein levels after minimally invasive esophagectomy for esophageal cancer.General thoracic and cardiovascular surgery · 2026Article
- Early CRP kinetics predict surgical outcomes in patients with Hartmann reversal.Frontiers in surgery · 2026Article
- The seven-day cumulative post-esophagectomy inflammatory response predicts cancer recurrence.BMC surgery · 2024Article
- Clinical impact of C-reactive protein to albumin ratio of the 7th postoperative day on prognosis after laparoscopic colorectal cancer surgery.Annals of coloproctology · 2023Article
- Prognostic impact of postoperative systemic inflammatory response in patients with stage II/III gastric cancer.Scientific reports · 2022Article
- Perioperative Predictive Markers for Recurrence of Esophageal Cancer after Esophagectomy.Gastrointestinal tumors · 2021Article
- Review
- The impact of postoperative inflammation on recurrence in patients with colorectal cancer.International journal of clinical oncology · 2020Article
- Early postoperative inflammatory response by procedure types: stapler-based segmentectomy versus lobectomy.General thoracic and cardiovascular surgery · 2020Article
- Significance of the 7th postoperative day neutrophil-to-lymphocyte ratio in colorectal cancer.International journal of colorectal disease · 2020Article
- Circulating microRNA/isomiRs as novel biomarkers of esophageal squamous cell carcinoma.PloS one · 2020Article
- Preoperative serum C-reactive protein levels and postoperative survival in patients with esophageal squamous cell carcinoma: a propensity score matching analysis.Journal of cardiothoracic surgery · 2019Article
- The postoperative peak number of leukocytes after hepatectomy is a significant prognostic factor for cholangiocarcinoma.Molecular and clinical oncology · 2019Article
- Meaning of C-reactive protein around esophagectomy for cStage III esophageal cancer.Surgery today · 2019Article
- Prognostic value of the combination of pre- and postoperative C-reactive protein in colorectal cancer patients.Surgery today · 2018Article
- Minimally invasive esophagectomy in the prone position improves postoperative outcomes: role of C-reactive protein as an indicator of surgical invasiveness.Esophagus : official journal of the Japan Esophageal Society · 2018Article
- Lnc2Catlas: an atlas of long noncoding RNAs associated with risk of cancers.Scientific reports · 2018Article
- Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care.In vivo (Athens, Greece)Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated preoperative serum C-reactive protein (CRP) levels are reportedly associated with a poor prognosis for patients with various types of malignant tumors. However, the impact of postoperative CRP levels on the prognosis of patients with esophageal cancer remains unknown. The present study aims to clarify the prognostic significance of postoperative CRP levels on the survival of patients with esophageal cancer.
methodsWe reviewed the records of consecutive 202 patients with thoracic esophageal squamous cell carcinoma who underwent transthoracic esophagectomy. We measured serum CRP levels on postoperative days (PODs) 1, 2, 3, 5 and 7 and evaluated the relationships between postoperative CRP levels and survival.
resultsThe findings of Cox regression analyses suggested that elevated CRP levels on POD 3, 5 and 7 were associated with poor recurrence-free survival (RFS). We divided CRP levels on POD 7 into three tertiles and found that RFS could be clearly stratified, being the poorest (p < 0.001) in the highest tertile (high CRP). The trend was similar even in patients with or without infectious complications and with or without advanced pathological stage. Multivariate analysis showed that pathologically advanced stage (Hazard ratio [HR], 5.14; 95% confidence interval [CI] 2.67-9.87; p < 0.001) and high CRP (HR, 2.27; 95% CI 1.3-3.96; p = 0.004) were independent predictors of RFS.
conclusionPostoperative CRP levels could predict the prognosis of patients with esophageal cancer. We propose that the clinical course of postoperative CRP level should be carefully monitored as a predictor of survival.
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