Evidence map›Paper›PMID 28120003›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2017

PET imaging of α

Ansel T Hillmer, Songye Li, Ming-Qiang Zheng, Matthias Scheunemann, Shu-Fei Lin, Nabeel Nabulsi, Daniel Holden, Richard Pracitto, David Labaree, Jim Ropchan and 7 more

Abstract readComparative Study
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. "Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. EJNMMI research · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Development ofACS chemical neuroscience · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. RSC advances · 2021
    Article
  18. Frontiers in bioengineering and biotechnology · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Ansel T HillmerPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA. ansel.hillmer@yale.edu.
Songye LiPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Ming-Qiang ZhengPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Matthias ScheunemannHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.
Shu-Fei LinPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Nabeel NabulsiPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Daniel HoldenPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Richard PracittoPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
David LabareePET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Jim RopchanPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Rodrigo TeodoroHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.
Winnie Deuther-ConradHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.
Irina EsterlisPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Kelly P CosgrovePET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Peter BrustHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.
Richard E CarsonPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Yiyun HuangPET Center, Yale University, PO Box 208048, 801 Howard Ave, New Haven, CT, 06520-8048, USA.
Yale Cancer Center · USHelmholtz-Zentrum Dresden-Rossendorf · DEYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Imaging Molecular Mechanisms of Tobacco Smoking WithdrawalR01DA038832 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2016 to 2021
$3.6M
Tobacco Smoking &Nicotinic Acetylcholine ReceptorsR01DA015577 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2004 to 2013
$3.4M
Role of Beta2-nAChR in Bipolar DisorderK01MH092681 · NIMH · YALE UNIVERSITY · PI ESTERLIS, IRINA · 2011 to 2015
$850k
Imaging Genetics in Tobacco SmokersK02DA031750 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2012 to 2016
$634k
NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NIDA NIH HHS K02 DA031750NIDA NIH HHS R01 DA015577NIDA NIH HHS R01 DA038832NIDA NIH HHS T32 DA022975NIMH NIH HHS K01 MH092681
6 · The paper itself

Abstract

purposeThe α

methodsPET scans with high specific activity [

resultsIn the rhesus monkey brain [

conclusionsThese results confirm [

Indexed as

Azabicyclo CompoundsCyclic S-Oxidesalpha7 Nicotinic Acetylcholine ReceptorAnimalsFemaleHumansImage Processing, Computer-AssistedKineticsMacaca mulattaMalePositron-Emission TomographyReproducibility of Results3-(1,4-diazabicyclo(3.2.2)nonan-4-yl)-6-fluorodibenzo(b,d)thiophene 5,5-dioxidealpha7 Nicotinic Acetylcholine ReceptorAzabicyclo CompoundsCyclic S-OxidesDBT-10Alpha7ASEMNicotineNicotinic Acetylcholine ReceptorPET

Identifiers

PMID28120003
PMCPMC5400702
OpenAlexW2581203384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.