ArticleFrontiers in genetics2016
Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.
Article in Frontiers in genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Advancing Epidermal Barrier Resilience in Atopic Dermatitis with Isosorbide Di-Fatty Acid Esters: From Disruption to Restoration.Biomolecules · 2026Review
- A spatial human thymus cell atlas mapped to a continuous tissue axis.bioRxiv : the preprint server for biology · 2023Article
- Tensor Decomposition-based Feature Extraction and Classification to Detect Natural Selection from Genomic Data.Molecular biology and evolution · 2023Article
- Rapid divergence of a gamete recognition gene promoted macroevolution of Eutheria.Genome biology · 2022Article
- Article
- The Epidermis: Redox Governor of Health and Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Seeing Keratinocyte Proteins through the Looking Glass of Intrinsic Disorder.International journal of molecular sciences · 2021Review
- The evolution of human skin pigmentation involved the interactions of genetic, environmental, and cultural variables.Pigment cell & melanoma research · 2021Review
- Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa.Nature communications · 2021Article
- Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution.Frontiers in genetics · 2021Article
- Evolutionary context of psoriatic immune skin response.Evolution, medicine, and public health · 2021Article
- The KEAP1/NRF2 Signaling Pathway in Keratinization.Antioxidants (Basel, Switzerland) · 2020Review
- Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis.International journal of molecular sciences · 2020Review
- The evolution of S100A7 in primates: a model of concerted and birth-and-death evolution.Immunogenetics · 2019Article
- Recent evolution of the human skin barrier.Experimental dermatology · 2018Review
- Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals.Oncotarget · 2018Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The epidermal differentiation complex (EDC) is the most rapidly evolving locus in the human genome compared to that of the chimpanzee. Yet the EDC genes that are undergoing positive selection across mammals and in humans are not known. We sought to identify the positively selected genetic variants and determine the evolutionary events of the EDC using mammalian-wide and clade-specific branch- and branch-site likelihood ratio tests and a genetic algorithm (GA) branch test. Significant non-synonymous substitutions were found in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.