Evidence map›Paper›PMID 28119599›Full record

ArticleFrontiers in aging neuroscience2016

Early Age-Related Functional Connectivity Decline in High-Order Cognitive Networks.

Tali Siman-Tov, Noam Bosak, Elliot Sprecher, Rotem Paz, Ayelet Eran, Judith Aharon-Peretz, Itamar Kahn

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Ulinastatin Protects Cognition in Cardiac Surgical Patients.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026
    Trial
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  6. Article
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  10. Age-Related Hearing Decline and Resting-State Networks.American journal of audiology · 2025
    Article
  11. Article
  12. Article
  13. Brain Resting-state Functional Connectivity Mediates the Age-associated Decline in Physical Activity Engagement.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  14. Article
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  16. Article
  17. Article
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tali Siman-TovCognitive Neurology Institute, Rambam Health Care Campus Haifa, Israel.
Noam BosakDepartment of Neuroscience, Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology Haifa, Israel.
Elliot SprecherLaboratory of Clinical Neurophysiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of TechnologyHaifa, Israel; Department of Neurology, Rambam Health Care CampusHaifa, Israel.
Rotem PazCognitive Neurology Institute, Rambam Health Care Campus Haifa, Israel.
Ayelet EranDepartment of Diagnostic Imaging, Rambam Health Care Campus Haifa, Israel.
Judith Aharon-PeretzCognitive Neurology Institute, Rambam Health Care CampusHaifa, Israel; Department of Neurology, Rambam Health Care CampusHaifa, Israel.
Itamar KahnDepartment of Neuroscience, Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology Haifa, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the world ages, it becomes urgent to unravel the mechanisms underlying brain aging and find ways of intervening with them. While for decades cognitive aging has been related to localized brain changes, growing attention is now being paid to alterations in distributed brain networks. Functional connectivity magnetic resonance imaging (fcMRI) has become a particularly useful tool to explore large-scale brain networks; yet, the temporal course of connectivity lifetime changes has not been established. Here, an extensive cross-sectional sample (21-85 years old,

Indexed as

agingbrain networksfunctional connectivitylifespanMRIresting state

Identifiers

PMID28119599
PMCPMC5223363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.