ArticleFrontiers in synaptic neuroscience2016
The Role of Neuromodulators in Cortical Plasticity. A Computational Perspective.
Article in Frontiers in synaptic neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Contribution of Glutamatergic and GABAergic Mechanisms to the Plasticity-Modulating Effects of Dopamine in the Human Motor Cortex.Human brain mapping · 2025Trial
- Two-factor synaptic plasticity enables memory consolidation during neuronal burst firing.PNAS nexus · 2026Article
- Burst firing creates an attractor in synaptic weight dynamics.PLoS computational biology · 2026Article
- Three-factor learning in spiking neural networks: An overview of methods and trends from a machine learning perspective.Patterns (New York, N.Y.) · 2025Review
- Understanding the effects of transcranial direct current stimulation on the neurovascular unit: a narrative review.Frontiers in neuroscience · 2025Review
- Local extracellular KProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dendrites help mitigate the plasticity-stability dilemma.Scientific reports · 2023Article
- Astrocyte regulation of synaptic signaling in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Individual differences in frontoparietal plasticity in humans.NPJ science of learning · 2022Article
- Dendritic Excitability and Synaptic Plasticity In Vitro and In Vivo.Neuroscience · 2022Review
- The Origin of Abnormal Beta Oscillations in the Parkinsonian Corticobasal Ganglia Circuits.Parkinson's disease · 2022Review
- The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning.PLoS computational biology · 2021Article
- Situational Understanding in the Human and the Machine.Frontiers in systems neuroscience · 2021Article
- The interplay between somatic and dendritic inhibition promotes the emergence and stabilization of place fields.PLoS computational biology · 2020Article
- Autonomous emergence of connectivity assemblies via spike triplet interactions.PLoS computational biology · 2020Article
- Exploring Neuromodulation for Dynamic Learning.Frontiers in neuroscience · 2020Article
- Dopaminergic Modulation of Synaptic Plasticity, Its Role in Neuropsychiatric Disorders, and Its Computational Modeling.Basic and clinical neuroscienceReview
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2 authors.
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Abstract
Neuromodulators play a ubiquitous role across the brain in regulating plasticity. With recent advances in experimental techniques, it is possible to study the effects of diverse neuromodulatory states in specific brain regions. Neuromodulators are thought to impact plasticity predominantly through two mechanisms: the gating of plasticity and the upregulation of neuronal activity. However, the consequences of these mechanisms are poorly understood and there is a need for both experimental and theoretical exploration. Here we illustrate how neuromodulatory state affects cortical plasticity through these two mechanisms. First, we explore the ability of neuromodulators to gate plasticity by reshaping the learning window for spike-timing-dependent plasticity. Using a simple computational model, we implement four different learning rules and demonstrate their effects on receptive field plasticity. We then compare the neuromodulatory effects of upregulating learning rate versus the effects of upregulating neuronal activity. We find that these seemingly similar mechanisms do not yield the same outcome: upregulating neuronal activity can lead to either a broadening or a sharpening of receptive field tuning, whereas upregulating learning rate only intensifies the sharpening of receptive field tuning. This simple model demonstrates the need for further exploration of the rich landscape of neuromodulator-mediated plasticity. Future experiments, coupled with biologically detailed computational models, will elucidate the diversity of mechanisms by which neuromodulatory state regulates cortical plasticity.
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