ArticleScience signaling2017
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
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Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 110 citations in OpenAlex.
- CaThe Journal of physiology · 2026Article
- Aging Disrupts L-type CaCirculation research · 2026Article
- Context-Dependent Control: PKA Regulation of Vascular CaArteriosclerosis, thrombosis, and vascular biology · 2026Article
- TMEM16A channel signalling microdomains in the regulation of vascular function.The Journal of physiology · 2026Review
- Modulation of ion channels as emerging therapeutic targets in the treatment of diabetic neuropathy.EXCLI journal · 2026Review
- Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Amyloid β alters vascular CaThe Journal of physiology · 2025Article
- Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells.bioRxiv : the preprint server for biology · 2025Article
- Diabetes Differentially Affects Vascular Reactivity in Isolated Human Arterial and Venous Bypass Grafts.Life (Basel, Switzerland) · 2025Article
- 14-3-3 promotes sarcolemmal expression of cardiac CaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances.Frontiers in cell and developmental biology · 2025Review
- Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac CaBMC biology · 2024Article
- Red blood cell signaling is functionally conserved iniScience · 2024Article
- α1Journal of the American Heart Association · 2024Article
- α1Journal of the American Heart Association · 2024Article
- Aberrant splicing of CaCellular and molecular life sciences : CMLS · 2024Article
- Extracellular glucose and dysfunctional insulin receptor signaling independently upregulate arterial smooth muscle TMEM16A expression.American journal of physiology. Cell physiology · 2024Article
- Article
- A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle.bioRxiv : the preprint server for biology · 2024Article
- Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles.Frontiers in pharmacology · 2024Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Matthew A NystoriakDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Madeline Nieves-CintrónDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Tommaso PatriarchiDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Olivia R BuonaratiDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Maria Paz PradaDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Stefano MorottiDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Eleonora GrandiDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Julia Dos Santos FernandesDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Katherine ForbushHoward Hughes Medical Institute and Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Franz HofmannDepartment of Pharmacology and Toxicology, Technical University of Munich, Munich D80802, Germany.
Kent C SasseSasse Surgical Associates, Reno, NV 89502, USA.
John D ScottHoward Hughes Medical Institute and Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada, Reno, NV 89557, USA.
Johannes W HellDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Manuel F NavedoDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA. mfnavedo@ucdavis.edu.
University of California, Davis · USUniversity of Nevada, Reno · US
Funding
Project# 4: INTERACTIONS OF ANCHORING PROTEINS WITH THEIR TARGETSP01DK054441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR, SUSAN S. · 1999 to 2017
$27.3MProject 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HONG, KYUNG UK · 2012 to 2017
$13.8MCARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007828 · NHLBI · UNIVERSITY OF WASHINGTON · PI Francis Kim, Farid Moussavi-Harami · 1997 to 2026
$10.2MMechanisms underlying regional differences in gastric compliance in the stomach.R01DK057236 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KENTON M SANDERS, Sean M Ward · 2000 to 2026
$7.1MSex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0MCoupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5MRole of a-actinin in Cav1.2 FunctionR01AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2016 to 2026
$4.0MCalcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5MMolecular Mechanisms of Postsynaptic AMPA Receptor LocalizationR01MH097887 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2014 to 2018
$2.5MPredoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2MSignaling by cAMP within postsynaptic nano domains R01NS078792R01NS078792 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2016
$2.0MLocal Signaling in Diabetic ComorbiditiesR01DK105542 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2015 to 2018
$1.4MHoward Hughes Medical InstituteNHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL131517NHLBI NIH HHS T32 HL007828NIA NIH HHS R01 AG055357NIDDK NIH HHS P01 DK054441NIDDK NIH HHS R01 DK057236NIDDK NIH HHS R01 DK105542NIGMS NIH HHS P20 GM103492NIGMS NIH HHS T32 GM099608NIMH NIH HHS R01 MH097887NINDS NIH HHS R01 NS078792
Abstract
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in part, attributed to the effects of increased glucose (hyperglycemia) on L-type Ca
Indexed as
Acute DiseaseAdultAgedAnimalsCalcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesDiabetes Mellitus, Type 2Diet, High-FatFemaleGlucoseHumansHyperglycemiaImmunoblottingMaleMice, Inbred C57BLMice, KnockoutCalcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesGlucoseL-type calcium channel alpha(1C)Serine
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.