Evidence map›Paper›PMID 28119454›Full record

ArticleThe Journal of biological chemistry2017

Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma.

Hai Song, Chuwen Lin, Erica Yao, Kuan Zhang, Xiaoling Li, Qingzhe Wu, Pao-Tien Chuang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Regulating tumor suppressor genes: post-translational modifications.Signal transduction and targeted therapy · 2020
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hai SongFrom the Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China and.
Chuwen Linthe Cardiovascular Research Institute, University of California, San Francisco, California 94158.
Erica Yaothe Cardiovascular Research Institute, University of California, San Francisco, California 94158.
Kuan Zhangthe Cardiovascular Research Institute, University of California, San Francisco, California 94158.
Xiaoling LiFrom the Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China and.
Qingzhe WuFrom the Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China and.
Pao-Tien Chuangthe Cardiovascular Research Institute, University of California, San Francisco, California 94158 pao-tien.chuang@ucsf.edu.
University of California, San Francisco · USZhejiang University · CN

Funding

Epithelial Progenitor Cells in Lung Repair and RegenerationU01HL111054 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAPMAN, HAROLD A, CHUANG, PAO-TIEN · 2012 to 2016
$3.2M
The lineage and function of neuroendocrine cells in lung homeostasis and injuryR01HL115207 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHUANG, PAO-TIEN · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL115207NHLBI NIH HHS U01 HL111054
6 · The paper itself

Abstract

Among the four different types of thyroid cancer, treatment of medullary thyroid carcinoma poses a major challenge because of its propensity of early metastasis. To further investigate the molecular mechanisms of medullary thyroid carcinoma and discover candidates for targeted therapies, we developed a new mouse model of medullary thyroid carcinoma based on our

Indexed as

Genes, Tumor SuppressorAllelesAnimalsCalcitoninCalcitonin Gene-Related PeptideCarcinoma, NeuroendocrineCell DifferentiationCell LineCell ProliferationCell Transformation, NeoplasticDisease Models, AnimalDNA Mutational AnalysisFemaleGreen Fluorescent ProteinsHumansIntegrasesCalcitoninCalcitonin Gene-Related PeptideCre recombinaseGreen Fluorescent ProteinsIntegrasescalcitonincancer biologyCGRPgene knock-outgenomicsmedullary thyroid carcinomamouse geneticsparafollicular C cellstumor suppressor gene

Identifiers

PMID28119454
PMCPMC5339769
OpenAlexW2580537814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.