Evidence map›Paper›PMID 28119451›Full record

ArticleThe Journal of biological chemistry2017

Flavonoids Suppress

Jon E Paczkowski, Sampriti Mukherjee, Amelia R McCready, Jian-Ping Cong, Christopher J Aquino, Hahn Kim, Brad R Henke, Chari D Smith, Bonnie L Bassler

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 1 synthesis or guideline pooled it, 305 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Antibacterial and anti-virulence effects ofMicrobiology spectrum · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Antibacterial and Antibiofilm Activities of Bluestem (International journal of microbiology · 2026
    Article
  15. Review
  16. Disruption of quorum sensing and biofilm formation in Pseudomonas aeruginosa by plant-based O-methylated flavonoids.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. The H-NS homologues MvaT and MvaU repress CRISPR-Cas inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jon E PaczkowskiFrom the Department of Molecular Biology and.
Sampriti MukherjeeFrom the Department of Molecular Biology and.
Amelia R McCreadyFrom the Department of Molecular Biology and.
Jian-Ping CongFrom the Department of Molecular Biology and.
Christopher J AquinoCJA MedChem, Hillsborough, North Carolina 27278.
Hahn Kimthe Department of Chemistry, Small Molecule Screening Center, Princeton University, Princeton, New Jersey 08544.
Brad R HenkeOpti-Mol Consulting, LLC, Cary, North Carolina 27513, and.
Chari D SmithFrom the Department of Molecular Biology and.
Bonnie L BasslerFrom the Department of Molecular Biology and bbassler@princeton.edu.
Princeton University · USHoward Hughes Medical Institute · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Intra-and Inter-Species Communication in BacteriaR01GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2002 to 2015
$4.2M
Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM065859NIGMS NIH HHS R37 GM065859NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Quorum sensing is a process of cell-cell communication that bacteria use to regulate collective behaviors. Quorum sensing depends on the production, detection, and group-wide response to extracellular signal molecules called autoinducers. In many bacterial species, quorum sensing controls virulence factor production. Thus, disrupting quorum sensing is considered a promising strategy to combat bacterial pathogenicity. Several members of a family of naturally produced plant metabolites called flavonoids inhibit

Indexed as

Allosteric RegulationBacterial ProteinsBiofilmsFlavonoidsPseudomonas aeruginosaQuorum SensingSmall Molecule LibrariesStructure-Activity RelationshipTrans-ActivatorsVirulenceBacterial ProteinsFlavonoidsLasR protein, Pseudomonas aeruginosaRhlR protein, Pseudomonas aeruginosaSmall Molecule LibrariesTrans-Activatorsflavonoidinhibition mechanismPseudomonasquorum sensingvirulence factor

Identifiers

PMID28119451
PMCPMC5354481
OpenAlexW2582365431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.