Evidence map›Paper›PMID 28119399›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na

Yalan Zhang, Weiming Ni, Arthur L Horwich, Leonard K Kaczmarek

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1).FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Yalan ZhangDepartments of Pharmacology.
Weiming NiGenetics/Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520.
Arthur L HorwichGenetics/Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520.ORCID 0000-0001-9561-8839
Leonard K KaczmarekDepartments of Pharmacology, leonard.kaczmarek@yale.edu.ORCID 0000-0001-5128-6326
Howard Hughes Medical Institute · USHôpital Léon Bérard · FRInstitute of Pharmacology · CZ

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cellular regulation of Sodium-activated Ion ChannelsR01HD067517 · NICHD · YALE UNIVERSITY · PI KACZMAREK, LEONARD K · 2011 to 2015
$1.7M
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NICHD NIH HHS R01 HD067517
6 · The paper itself

Abstract

Mutations that alter levels of Slack (KCNT1) Na

Indexed as

AnimalsAplysiaBiophysicsCells, CulturedElectric StimulationEnzyme InhibitorsGanglia, InvertebrateHumansLuminescent ProteinsMembrane PotentialsMicroinjectionsMorpholinosMutationNerve Tissue ProteinsNeuronsPatch-Clamp TechniquesEnzyme InhibitorsKCNT1 protein, humanLuminescent ProteinsMorpholinosNerve Tissue ProteinsPotassium ChannelsPotassium Channels, Sodium-ActivatedRNA, Small InterferingSodiumSuperoxide Dismutase-1ALSSODsodium-activated potassium channel

Identifiers

PMID28119399
PMCPMC5338764
OpenAlexW2581617849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.