ArticleCerebral cortex (New York, N.Y. : 1991)2017
Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- A synthetic HS structure selectively impairs the morphology and function of excitatory synapse by disrupting neurexin1 interactions.Glycobiology · 2025Article
- Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure.eLife · 2024Article
- Hyaluronidase-induced matrix remodeling contributes to long-term synaptic changes.Frontiers in neural circuits · 2024Article
- Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines.Cellular and molecular life sciences : CMLS · 2023Article
- Article
- Article
- Rapid Fluorescence Lifetime Imaging Reveals That TRPV4 Channels Promote Dysregulation of Neuronal NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Heterogeneity and Development of Fine Astrocyte Morphology Captured by Diffraction-Limited Microscopy.Frontiers in cellular neuroscience · 2021Article
- A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.Science (New York, N.Y.) · 2020Article
- Article
- The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats.Iranian journal of basic medical sciences · 2020Article
- Local Resting CaCell reports · 2020Article
- Quantitative determination of cellular [NaThe Journal of general physiology · 2019Article
- HACE1 deficiency leads to structural and functional neurodevelopmental defects.Neurology. Genetics · 2019Article
- Heparanase in health and disease: The neglected housekeeper of the cell?Atherosclerosis · 2019Article
- Intra- and Extracellular Pillars of a Unifying Framework for Homeostatic Plasticity: A Crosstalk Between Metabotropic Receptors and Extracellular Matrix.Frontiers in cellular neuroscience · 2019Review
- Article
- Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.Brain : a journal of neurology · 2018Article
- Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS.Nature chemical biology · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heparan sulfate (HS) proteoglycans represent a major component of the extracellular matrix and are critical for brain development. However, their function in the mature brain remains to be characterized. Here, acute enzymatic digestion of HS side chains was used to uncover how HSs support hippocampal function in vitro and in vivo. We found that long-term potentiation (LTP) of synaptic transmission at CA3-CA1 Schaffer collateral synapses was impaired after removal of highly sulfated HSs with heparinase 1. This reduction was associated with decreased Ca2+ influx during LTP induction, which was the consequence of a reduced excitability of CA1 pyramidal neurons. At the subcellular level, heparinase treatment resulted in reorganization of the distal axon initial segment, as detected by a reduction in ankyrin G expression. In vivo, digestion of HSs impaired context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, HSs maintain neuronal excitability and, as a consequence, support synaptic plasticity and learning.
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Registered trials
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