Evidence map›Paper›PMID 28119018›Full record

ReviewNeurobiology of learning and memory2017

Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom.

Thekla J Hemstedt, K Matthew Lattal, Marcelo A Wood

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of learning and memory, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Molecular Mechanisms of Reconsolidation-Dependent Memory Updating.International journal of molecular sciences · 2020
    Review
  8. Histone deacetylase inhibitors rescue the impaired memory in terrestrial snails.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Thekla J HemstedtDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA; Center for the Neurobiology of Learning and Memory, Irvine, CA, USA.
K Matthew LattalDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA; Center for the Neurobiology of Learning and Memory, Irvine, CA, USA. Electronic address: mwood@uci.edu.
University of California, Irvine · USOregon Health & Science University · US

Funding

Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognitionR01AG051807 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI COTMAN, CARL WAYNE, WOOD, MARCELO ANDRES · 2016 to 2020
$3.1M
Role of Neuron-Specific Nucleosome Remodeling in Intellectual DisabilityR01MH101491 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYNCH, GARY S, WOOD, MARCELO ANDRES · 2013 to 2017
$2.3M
Role of HDAC3 in repressing memory formation in the aging brainR21AG050787 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2016 to 2017
$425k
Social modulation of acquisition and extinction of fearR21MH106284 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAHVIS, GARET PAUL, LATTAL, K MATTHEW · 2016 to 2017
$424k
NIA NIH HHS R01 AG051807NIA NIH HHS R21 AG050787NIMH NIH HHS R01 MH101491NIMH NIH HHS R21 MH106284
6 · The paper itself

Abstract

Epigenetic mechanisms have the potential to give rise to lasting changes in cell function that ultimately can affect behavior persistently. This concept is especially interesting with respect to fear reconsolidation and fear memory extinction. These two behavioral approaches are used in the laboratory to investigate how fear memory can be attenuated, which becomes important when searching for therapeutic intervention to treat anxiety disorders and post-traumatic stress disorder. Here we review the role of several key epigenetic mechanisms in reconsolidation and extinction of learned fear and their potential to persistently alter behavioral responses to conditioned cues. We also briefly discuss how epigenetic mechanisms may establish persistent behaviors that challenge our definitions of extinction and reconsolidation.

Indexed as

AcetylationAnimalsConditioning, PsychologicalDNA MethylationEpigenesis, GeneticExtinction, PsychologicalFearHistonesMemoryMemory ConsolidationHistonesDNA methylationEpigeneticsExtinctionHistone acetylationReconsolidation

Identifiers

PMID28119018
PMCPMC5457345
OpenAlexW2579895452

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.