ArticleGenetics, selection, evolution : GSE2017
Genome-wide association study for conformation traits in three Danish pig breeds.
Article in Genetics, selection, evolution : GSE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 6 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 6 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Integrated genome-wide association studies, meta-analysis, and Bayesian fine mapping reveal novel quantitative trait loci's and functional candidate genes for vulva traits in large white pigs.Journal of animal science · 2025Pooled it
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- GWAS of Reproductive Traits in Large White Pigs on Chip and Imputed Whole-Genome Sequencing Data.International journal of molecular sciences · 2022Pooled it
- A meta-analysis of genome-wide association studies for average daily gain and lean meat percentage in two Duroc pig populations.BMC genomics · 2021Pooled it
- Meta-analysis of genome-wide association studies for loin muscle area and loin muscle depth in two Duroc pig populations.PloS one · 2019Pooled it
- Genome-wide association studies and meta-analysis uncovers new candidate genes for growth and carcass traits in pigs.PloS one · 2018Pooled it
- Genome-Wide Association Study of Rib Number and Total Thoracolumbar Vertebrae Number in a Jishen Black Pig Population.Veterinary sciences · 2026Article
- Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach.Current issues in molecular biology · 2026Article
- Genomic characterization and insights into the belted coat pattern of a local, reconstituted pig population.Animal biotechnology · 2025Article
- Genome-wide detection of runs of homozygosity in Ding'an pigs revealed candidate genes relating to meat quality traits.BMC genomics · 2025Article
- Multiple association studies identify 3 novel candidate genes for teat number trait in Danish Landrace and Large White pigs: BRINP3, LIN52, and UBE3B.Journal of animal science · 2025Article
- Whole-genome resequencing revealed the genetic diversity and body weight-related genes of Gannan yak.Frontiers in veterinary science · 2025Article
- Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China.Animals : an open access journal from MDPI · 2024Review
- Article
- Genetic dissection of 26 meat cut, meat quality and carcass traits in four pig populations.Genetics, selection, evolution : GSE · 2023Article
- A genome-wide association study for loin depth and muscle pH in pigs from intensely selected purebred lines.Genetics, selection, evolution : GSE · 2023Article
- Identification of the genetic basis of sow pelvic organ prolapse.Frontiers in genetics · 2023Article
- Article
- Genome-Wide Association Studies Revealed Significant QTLs and Candidate Genes Associated with Backfat and Loin Muscle Area in Pigs Using Imputation-Based Whole Genome Sequencing Data.Animals : an open access journal from MDPI · 2022Article
- Genetic diversity and population structure of six autochthonous pig breeds from Croatia, Serbia, and Slovenia.Genetics, selection, evolution : GSE · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelection for sound conformation has been widely used as a primary approach to reduce lameness and leg weakness in pigs. Identification of genomic regions that affect conformation traits would help to improve selection accuracy for these lowly to moderately heritable traits. Our objective was to identify genetic factors that underlie leg and back conformation traits in three Danish pig breeds by performing a genome-wide association study followed by meta-analyses.
methodsData on four conformation traits (front leg, back, hind leg and overall conformation) for three Danish pig breeds (23,898 Landrace, 24,130 Yorkshire and 16,524 Duroc pigs) were used for association analyses. Estimated effects of single nucleotide polymorphisms (SNPs) from single-trait association analyses were combined in two meta-analyses: (1) a within-breed meta-analysis for multiple traits to examine if there are pleiotropic genetic variants within a breed; and (2) an across-breed meta-analysis for a single trait to examine if the same quantitative trait loci (QTL) segregate across breeds. SNP annotation was implemented through Sus scrofa Build 10.2 on Ensembl to search for candidate genes.
resultsAmong the 14, 12 and 13 QTL that were detected in the single-trait association analyses for the three breeds, the most significant SNPs explained 2, 2.3 and 11.4% of genetic variance for back quality in Landrace, overall conformation in Yorkshire and back quality in Duroc, respectively. Several candidate genes for these QTL were also identified, i.e. LRPPRC, WRAP73, VRTN and PPARD likely control conformation traits through the regulation of bone and muscle development, and IGF2BP2, GH1, CCND2 and MSH2 can have an influence through growth-related processes. Meta-analyses not only confirmed many significant SNPs from single-trait analyses with higher significance levels, but also detected several additional associated SNPs and suggested QTL with possible pleiotropic effects.
conclusionsOur results imply that conformation traits are complex and may be partly controlled by genes that are involved in bone and skeleton development, muscle and fat metabolism, and growth processes. A reliable list of QTL and candidate genes was provided that can be used in fine-mapping and marker assisted selection to improve conformation traits in pigs.
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