ArticlePLoS neglected tropical diseases2017
Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Sterile protection againstLife science alliance · 2024Article
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- How can the complex epidemiology of malaria in India impact its elimination?Trends in parasitology · 2023Review
- Naturally acquired antibody response toFrontiers in cellular and infection microbiology · 2023Article
- IgM antibody responses againstFrontiers in cellular and infection microbiology · 2023Article
- Advances in Basic and Translational Research as Part of the Center for the Study of Complex Malaria in India.The American journal of tropical medicine and hygiene · 2022Article
- Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India.The American journal of tropical medicine and hygiene · 2022Article
- The Impact, Emerging Needs, and New Research Questions Arising from 12 Years of the Center for the Study of Complex Malaria in India.The American journal of tropical medicine and hygiene · 2022Article
- Antibody signatures of asymptomatic Plasmodium falciparum malaria infections measured from dried blood spots.Malaria journal · 2021Article
- Article
- Decoding the complexities of human malaria through systems immunology.Immunological reviews · 2020Review
- Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India.Malaria journal · 2019Article
- Hospital-derived antibody profiles of malaria patients in Southwest India.Malaria journal · 2019Article
- Distinct Antibody Signatures Associated with Different Malaria Transmission Intensities in Zambia and Zimbabwe.mSphere · 2019Article
- Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax.Proteomics. Clinical applications · 2018Review
- Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure.PLoS neglected tropical diseases · 2018Article
- KILchip v1.0: A NovelFrontiers in immunology · 2018Article
- Article
- Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions.PLoS neglected tropical diseases · 2017Article
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23 authors.
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Abstract
Understanding naturally acquired immune responses to Plasmodium in India is key to improving malaria surveillance and diagnostic tools. Here we describe serological profiling of immune responses at three sites in India by probing protein microarrays consisting of 515 Plasmodium vivax and 500 Plasmodium falciparum proteins with 353 plasma samples. A total of 236 malaria-positive (symptomatic and asymptomatic) plasma samples and 117 malaria-negative samples were collected at three field sites in Raurkela, Nadiad, and Chennai. Indian samples showed significant seroreactivity to 265 P. vivax and 373 P. falciparum antigens, but overall seroreactivity to P. vivax antigens was lower compared to P. falciparum antigens. We identified the most immunogenic antigens of both Plasmodium species that were recognized at all three sites in India, as well as P. falciparum antigens that were associated with asymptomatic malaria. This is the first genome-scale analysis of serological responses to the two major species of malaria parasite in India. The range of immune responses characterized in different endemic settings argues for targeted surveillance approaches tailored to the diverse epidemiology of malaria across the world.
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