ArticleJournal of pediatric gastroenterology and nutrition2017
Utility of Gastric and Duodenal Biopsies During Follow-up Endoscopy in Children With Eosinophilic Esophagitis.
Article in Journal of pediatric gastroenterology and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.Gastroenterology · 2018Guideline
- Do Routine Gastric and Duodenal Biopsies Add Value in Patients with Eosinophilic Esophagitis? Evidence from a Large Single-Center Case Registry.Diagnostics (Basel, Switzerland) · 2026Article
- Segmental overlap is common in eosinophilic gastrointestinal diseases and impacts clinical presentation and treatment.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025Article
- A Single-Food Milk Elimination Diet Is Effective for Treatment of Eosinophilic Esophagitis in Children.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Observational
- Systematic review and meta-analysis of the incidence rates of adverse events after digestive endoscopy in children.Translational pediatrics · 2022Article
- Clonally expanded, GPR15-expressing pathogenic effector TScience immunology · 2021Article
- Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis.European journal of pediatrics · 2021Article
- Endoscopic Features and Diagnostic Procedures of Eosinophilic Gastroenteritis.Internal medicine (Tokyo, Japan) · 2019Article
- Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions.Journal of pediatric gastroenterology and nutrition · 2018Review
- Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesEosinophilic esophagitis (EoE) is a chronic antigen-mediated immune disorder of the esophagus. Consensus guidelines recommend obtaining esophageal, gastric, and duodenal biopsies at diagnostic endoscopy when EoE is suspected. The utility of repeated gastric and duodenal biopsies during follow-up endoscopy in patients previously diagnosed with EoE is not established. The aim of the present study was to explore the role of gastric and duodenal biopsies in children with an established diagnosis of EoE undergoing repeat endoscopy to assess histological response to treatment.
methodsRetrospective chart review of children diagnosed with EoE at a tertiary care center was conducted. A total of 160 patients with EoE with demographic clinical, endoscopic, and histological data at diagnosis and follow-up endoscopy were included. The frequency of gastric and duodenal biopsies at follow-up endoscopy with abnormal histology and their correlation to endoscopic findings was determined.
resultsAt follow-up endoscopy, 83% (132/160) of patients had gastric and 74% (118/160) had duodenal biopsies. Histology was normal in 81% of gastric and 92% of duodenal biopsies. The most frequent gastric abnormalities were chemical and inactive chronic gastritis. The most frequent duodenal abnormality was villous blunting with increased intraepithelial lymphocytes. Two patients with normal gastric and duodenal histology progressed to eosinophilic gastroenteritis at follow-up endoscopy.
conclusionsGastric and duodenal biopsies obtained in EoE patients during follow-up endoscopy show pathology in a minority of patients, increase costs, and may add potential risk of adverse events. Large multicenter, prospective studies of endoscopic practice during follow-up of EoE are warranted to provide evidence supporting best practices.
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