ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
Intermittent Aortic Valve Opening and Risk of Thrombosis in Ventricular Assist Device Patients.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- Embolic Transport in LVAD Outflow: An Experimental Study Using Patient-Specific and Idealized Aortic Models.Annals of biomedical engineering · 2026Article
- Preoperative Left Ventricular Thrombus and Midterm Outcomes Following Left Ventricular Assist Device Support.Journal of clinical medicine · 2026Article
- Incidence and clinical implications of aortic root thrombosis in LVAD patients: A single-center experience.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Percutaneous Mechanical Aspiration of an Aortic Root Thrombus Causing a Myocardial Infarction.JACC. Case reports · 2025Article
- Understanding embolus transport and source to destination mapping of thromboemboli in hemodynamics driven by left ventricular assist device.Scientific reports · 2025Article
- Pregnancy with a Left Ventricular Assist Device: A Narrative Review.Annals of cardiac anaesthesia · 2025Review
- Enhancing the implantation of mechanical circulatory support devices using computational simulations.Frontiers in bioengineering and biotechnology · 2024Article
- Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation.Annals of biomedical engineering · 2023Article
- Pathophysiology and management of valvular disease in patients with destination left ventricular assist devices.Frontiers in cardiovascular medicine · 2022Review
- Pump position and thrombosis in ventricular assist devices: Correlation of radiographs and CT data.The International journal of artificial organs · 2021Article
- Ventricular Flow Field Visualization During Mechanical Circulatory Support in the Assisted Isolated Beating Heart.Annals of biomedical engineering · 2020Article
- Pulsatile arterial blood pressure mimicking aortic valve opening during continuous-flow LVAD support: a case report.Journal of cardiothoracic surgery · 2019Article
- Small Left Ventricular Size Is an Independent Risk Factor for Ventricular Assist Device Thrombosis.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2019Article
- A Novel Control Method for Rotary Blood Pumps as Left Ventricular Assist Device Utilizing Aortic Valve State Detection.BioMed research international · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The current study evaluates quantitatively the impact that intermittent aortic valve (AV) opening has on the thrombogenicity in the aortic arch region for patients under left ventricular assist device (LVAD) therapy. The influence of flow through the AV, opening once every five cardiac cycles, on the flow patterns in the ascending aortic is measured in a patient-derived computed tomography image-based model, after LVAD implantation. The mechanical environment of flowing platelets is investigated, by statistical treatment of outliers in Lagrangian particle tracking, and thrombogenesis metrics (platelet residence times and activation state characterized by shear stress accumulation) are compared for the cases of closed AV versus intermittent AV opening. All hemodynamics metrics are improved by AV opening, even at a reduced frequency and flow rate. Residence times of platelets or microthrombi are reduced significantly by transvalvular flow, as are the shear stress history experienced and the shear stress magnitude and gradients on the aortic root endothelium. The findings of this device-neutral study support the multiple advantages of management that enables AV opening, providing a rationale for establishing this as a standard in long-term treatment and care for advanced heart failure patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.