ArticleAIDS (London, England)2017
Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria.
Article in AIDS (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Gut microbiome in people living with HIV is associated with impaired thiamine and folate syntheses.Microbial pathogenesis · 2021Pooled it
- The Impact of Human Immunodeficiency Virus Infection on Gut Microbiota α-Diversity: An Individual-level Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- Gut Microbiome Changes Associated With HIV Infection and Sexual Orientation.Frontiers in cellular and infection microbiology · 2020Pooled it
- Bacterial fecal microbiome composition associated with HIV stage among rural and peri-urban adults living with HIV in Uganda.BMC infectious diseases · 2026Article
- Metagenomic analysis reveals rectal microbiota features associated with HIV and behavioral factors in Nigerian men who have sex with men.Scientific reports · 2026Article
- Linking the relationship between drug-induced osteoporosis and the gut microbiota.Frontiers in endocrinology · 2026Review
- Gut Microbiome Alteration in HIV/AIDS and the Role of Antiretroviral Therapy-A Scoping Review.Microorganisms · 2024Article
- The Gut and the Translocated Microbiomes in HIV Infection: Current Concepts and Future Avenues.Pathogens & immunity · 2024Review
- Crosstalk between human immunodeficiency virus infection and salivary bacterial function in men who have sex with men.Frontiers in cellular and infection microbiology · 2024Article
- A Scoping Review Evaluating the Current State of Gut Microbiota Research in Africa.Microorganisms · 2023Article
- Therapeutically targeting the consequences of HIV-1-associated gastrointestinal dysbiosis: Implications for neurocognitive and affective alterations.Pharmacology, biochemistry, and behavior · 2023Article
- Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer.Nature medicine · 2023Article
- Antenatal gut microbiome profiles and effect on pregnancy outcome in HIV infected and HIV uninfected women in a resource limited setting.BMC microbiology · 2023Article
- HIV and Mediterranean Zoonoses: A Review of the Literature.Infectious disease reports · 2022Review
- Acute exposure to simulated high-altitude hypoxia alters gut microbiota in mice.Archives of microbiology · 2022Article
- Exploring the Anal Microbiome in HIV Positive and High-Risk HIV Negative Women.AIDS research and human retroviruses · 2022Article
- Changes in Conjunctival Microbiota Associated With HIV Infection and Antiretroviral Therapy.Investigative ophthalmology & visual science · 2021Observational
- Meta-analysis methods for multiple related markers: Applications to microbiome studies with the results on multiple α-diversity indices.Statistics in medicine · 2021Article
- Altered Gut Microbiome under Antiretroviral Therapy: Impact of Efavirenz and Zidovudine.ACS infectious diseases · 2021Article
- Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China.Experimental and therapeutic medicine · 2021Article
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
Abstract
objectiveUntreated advanced HIV infection alters the gut microbiota, but it is unclear whether antiretroviral therapy (ART) reverses these changes. We compared the composition of the rectal microbiota among three groups of men who have sex with men (MSM): HIV-uninfected, untreated HIV, and ART-treated HIV-infected.
designA cross-sectional study was conducted among 130 MSM (55 HIV-uninfected, 41 untreated HIV, and 34 ART-treated HIV) in Abuja, Nigeria.
methodsBacterial 16S rRNA genes were amplified from rectal swabs, sequenced and clustered into Genera-level operational taxonomic units. Alpha diversity was quantified using the Shannon index and compared among groups using the Kruskal-Wallis test; associations with other scale variables were quantified using Spearman's rank correlation (Rs). The relative abundance of the top 15 taxa was compared according to HIV infection/treatment status using the Wilcoxon rank sum test.
resultsHIV-treated MSM had a decrease in a commensal phylum, Bacteroidetes (P < 0.01). Alpha diversity was positively correlated with viral loads (Rs = 0.32, P < 0.01). Statistically significant shifts in relative abundance of rectal microbiota for the HIV-treated group included a decrease in the most abundant bacteria, Prevotella (P = 0.02) and an increase in pathogenic bacteria, Peptoniphilus (P = 0.04), Finegoldia (P = 0.01), Anaerococcus (P = 0.03), and Campylobacter (P = 0.03) compared with the other groups.
conclusionUntreated HIV infection does not significantly alter the rectal microbiota, whereas prior treatment is associated with a shift toward a more pathogenic pattern of microbiota. Treatment with an antibiotic, co-trimoxazole, in conjunction with ART may have contributed to this shift.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.