Evidence map›Paper›PMID 28118114›Full record

ArticleRadiation research2017

Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G

Hatsumi Nagasawa, Yu-Fen Lin, Takamitsu A Kato, John R Brogan, Hung-Ying Shih, Akihiro Kurimasa, Joel S Bedford, Benjamin P C Chen, John B Little

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Analysis for Sister Chromatid Exchange.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hatsumi Nagasawaa   Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523.
Yu-Fen Linb   Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390.
Takamitsu A Katoa   Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523.
John R Brogana   Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523.
Hung-Ying Shihb   Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390.
Akihiro Kurimasac   Tohoku Medical and Pharmaceutical University, Sendai, Japan, 981-8558; and.
Joel S Bedforda   Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523.
Benjamin P C Chenb   Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390.
John B Littled   Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115.
Colorado State University · USThe University of Texas Southwestern Medical Center · USHarvard University · USTohoku Medical and Pharmaceutical University · JP

Funding

DNA-PKcs Phosphorylation on Hematopoietic Stem Cells Genome MaintenanceR01CA166677 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, BENJAMIN PING-CHI · 2012 to 2016
$1.6M
NCI NIH HHS R01 CA166677
6 · The paper itself

Abstract

The catalytic subunit of DNA dependent protein kinase (DNA-PKcs) and its kinase activity are critical for mediation of non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSB) in mammalian cells after gamma-ray irradiation. Additionally, DNA-PKcs phosphorylations at the T2609 cluster and the S2056 cluster also affect DSB repair and cellular sensitivity to gamma radiation. Previously we reported that phosphorylations within these two regions affect not only NHEJ but also homologous recombination repair (HRR) dependent DSB repair. In this study, we further examine phenotypic effects on cells bearing various combinations of mutations within either or both regions. Effects studied included cell killing as well as chromosomal aberration induction after 0.5-8 Gy gamma-ray irradiation delivered to synchronized cells during the G

Indexed as

Alpha ParticlesAnimalsCHO CellsChromosome AberrationsCricetinaeCricetulusDNA-Activated Protein KinaseG1 PhaseGamma RaysResting Phase, Cell CycleSerineThreonineDNA-Activated Protein KinaseSerineThreonine

Identifiers

PMID28118114
PMCPMC5319878
OpenAlexW2580932079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.