Evidence map›Paper›PMID 28118081›Full record

ReviewSmall GTPases2019

Rabs on the fly: Functions of Rab GTPases during development.

Sara Caviglia, David Flores-Benitez, Johanna Lattner, Stefan Luschnig, Marko Brankatschk

Open access · hybridAbstract readReview
In one paragraph

Review in Small GTPases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Sara Cavigliaa Danish Stem Cell Center (DanStem), University of Copenhagen , Copenhagen , Denmark.ORCID 0000-0001-9832-2566
David Flores-Benitezb Max Planck Institute for Cell Biology and Genetics (MPI-CBG) , Dresden , Germany.
Johanna Lattnerb Max Planck Institute for Cell Biology and Genetics (MPI-CBG) , Dresden , Germany.
Stefan Luschnigc Institute of Molecular Life Sciences and Ph.D. Program in Molecular Life Sciences, University of Zurich , Zurich , Switzerland.ORCID 0000-0002-0634-3368
Marko Brankatschke The Biotechnological Center of the TU Dresden (BIOTEC) , Dresden , Germany.ORCID 0000-0001-5274-4552
Max Planck Institut für Zellbiologie · DETechnische Universität Dresden · DEUniversity of Copenhagen · DKUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The organization of intracellular transport processes is adapted specifically to different cell types, developmental stages, and physiologic requirements. Some protein traffic routes are universal to all cells and constitutively active, while other routes are cell-type specific, transient, and induced under particular conditions only. Small GTPases of the Rab (Ras related in brain) subfamily are conserved across eukaryotes and regulate most intracellular transit pathways. The complete sets of Rab proteins have been identified in model organisms, and molecular principles underlying Rab functions have been uncovered. Rabs provide intracellular landmarks that define intracellular transport sequences. Nevertheless, it remains a challenge to systematically map the subcellular distribution of all Rabs and their functional interrelations. This task requires novel tools to precisely describe and manipulate the Rab machinery in vivo. Here we discuss recent findings about Rab roles during development and we consider novel approaches to investigate Rab functions in vivo.

Indexed as

AnimalsDrosophila melanogasterrab GTP-Binding Proteinsrab GTP-Binding Proteinscell polaritylysosome related organelles (LROs)Rab GTPasesStaccato/Munc13-4

Identifiers

PMID28118081
PMCPMC6380344
OpenAlexW2582785681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.