Evidence map›Paper›PMID 28118027›Full record

ArticleAmerican journal of respiratory cell and molecular biology2017

Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin.

Maya Mikami, Yi Zhang, Jennifer Danielsson, Tiarra Joell, Hwan Mee Yong, Elizabeth Townsend, Seema Khurana, Steven S An, Charles W Emala

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Gelsolin as a predictor of arteriovenous fistula maturation.Clinical and experimental nephrology · 2025
    Article
  2. β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  3. Article
  4. Article
  5. Bitter Taste Receptors in the Airway Cells Functions.Handbook of experimental pharmacology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Airway smooth muscle photorelaxation via opsin receptor activation.American journal of physiology. Lung cellular and molecular physiology · 2019
    Article
  10. Review
  11. Article
  12. Article
  13. Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reproductive sciences (Thousand Oaks, Calif.) · 2018
    Article
  14. Transient stretch induces cytoskeletal fluidization through the severing action of cofilin.American journal of physiology. Lung cellular and molecular physiology · 2018
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maya Mikami1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York.
Yi Zhang1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York.
Jennifer Danielsson1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York.
Tiarra Joell2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Hwan Mee Yong2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Elizabeth Townsend1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York.
Seema Khurana3 Department of Biology and Biochemistry, University of Houston, Baylor College of Medicine, Houston, Texas; and.
Steven S An2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Charles W Emala1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York.
Columbia University · USJohns Hopkins University · US

Funding

ANESTHESIOLOGY RESEARCH TRAININGT32GM008464 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHARLES W EMALA, May Hua · 1992 to 2026
$6.0M
Neuromuscular blocker-induced asthma during anesthesiaR01GM065281 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2003 to 2018
$5.4M
Nrf2 as a critical determinant of smooth muscle functionR01HL107361 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AN, STEVEN S · 2011 to 2015
$2.0M
Epithelial mesenchymal transition in gastrointestinal homeostasis and diseaseR01DK098120 · NIDDK · UNIVERSITY OF HOUSTON · PI KHURANA, SEEMA · 2013 to 2017
$1.6M
Targeting airway smooth muscle chloride fluxes for bronchorelaxationR01HL122340 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL107361NHLBI NIH HHS R01 HL122340NIDDK NIH HHS R01 DK098120NIGMS NIH HHS R01 GM065281NIGMS NIH HHS T32 GM008464
6 · The paper itself

Abstract

Diverse classes of ligands have recently been discovered that relax airway smooth muscle (ASM) despite a transient increase in intracellular calcium concentrations ([Ca

Indexed as

ActinsAnimalsBiomechanical PhenomenaCell SeparationChloroquineElectric ImpedanceGelsolinInositol PhosphatesLungMaleMice, Inbred C57BLMice, KnockoutMuscle RelaxationMuscle, SmoothMyocytes, Smooth MuscleReceptors, G-Protein-CoupledActinsChloroquineGelsolinInositol PhosphatesReceptors, G-Protein-Coupledactin cytoskeletonbitter taste receptor agonistcell stiffnessflexiVentsmooth muscle relaxation

Identifiers

PMID28118027
PMCPMC5449493
OpenAlexW2592561057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.