Evidence map›Paper›PMID 28117924›Full record

ReviewThe American journal on addictions2017

Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations.

Karen G Chartier, Katherine J Karriker-Jaffe, Cory R Cummings, Kenneth S Kendler

Abstract readReview
In one paragraph

Review in The American journal on addictions, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  8. Review
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  12. Observational
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  15. Recent advances in genetic studies of alcohol use disorders.Current genetic medicine reports · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen G ChartierSchool of Social Work, Virginia Commonwealth University, Richmond, Virginia.
Katherine J Karriker-JaffeAlcohol Research Group, Public Health Institute, Emeryville, California.
Cory R CummingsSchool of Social Work, Virginia Commonwealth University, Richmond, Virginia.
Kenneth S KendlerDepartment of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.

Funding

Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Brien P Riley · 2014 to 2026
$19.6M
An Alcohol Affected Sib Pair Study of Alcohol DependenceR37AA011408 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN · 2007 to 2016
$6.5M
Social, Developmental and Genetic Epidemiology of Alcohol Use DisordersR01AA023534 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN, SUNDQUIST, KRISTINA · 2015 to 2023
$4.0M
Ethnicity and alcohol dependence: Phenotypes, genes, and the social environmentK01AA021145 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHARTIER, KAREN G. · 2012 to 2016
$536k
NIAAA NIH HHS K01 AA021145NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA023534NIAAA NIH HHS R37 AA011408
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThis review aimed to inform the current state of alcohol research on the joint effects of genes and the environment conducted in U.S. racial/ethnic minority populations, focusing on African Americans, Latinos/Hispanics, Asians, and American Indians.

methodsA key-word and author-based search was conducted and supplemented with direct contact to researchers in this area to ensure a comprehensive inclusion of published, peer-reviewed studies. These studies were considered in terms of the racial/ethnic population groups, phenotypes, genetic variants, and environmental influences covered. Research findings from alcohol epidemiologic studies were highlighted to introduce some potential environmental variables for future studies of gene and environment (G-E) relationships.

resultsTwenty-six (N = 26) studies were reviewed. They predominantly involved African American and Asian samples and had a very limited focus on Latinos/Hispanics and American Indians. There was a wide range of alcohol-related phenotypes examined, and studies almost exclusively used a candidate gene approach. Environmental influences focused on the most proximate social network relationships with family and peers. There was far less examination of community- and societal-level environmental influences on drinking. Epidemiologic studies informing the selection of potential environmental factors at these higher order levels suggest inclusion of indicators of drinking norms, alcohol availability, socioeconomic disadvantage, and unfair treatment.

conclusionsThe review of current literature identified a critical gap in the study of environments: There is the need to study exposures at community and societal levels. SCIENTIFIC SIGNIFICANCE: These initial studies provide an important foundation for evolving the dialogue and generating other investigations of G-E relationships in diverse racial/ethnic groups. (Am J Addict 2017;26:446-460).

Indexed as

Gene-Environment InteractionAlcohol DrinkingAsianBlack or African AmericanHispanic or LatinoHumansIndians, North AmericanUnited States

Identifiers

PMID28117924
PMCPMC5695556

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.