ArticleTranslational psychiatry2017
Default mode network deactivation during emotion processing predicts early antidepressant response.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis.BMC psychiatry · 2025Pooled it
- Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review.Brain and behavior · 2025Pooled it
- A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing.Translational psychiatry · 2025Trial
- Acute neurofunctional effects of escitalopram during emotional processing in pediatric anxiety: a double-blind, placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression.Human brain mapping · 2020Trial
- Effects of Ketamine on Brain Activity During Emotional Processing: Differential Findings in Depressed Versus Healthy Control Participants.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- Prefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study.Translational psychiatry · 2019Trial
- Rostral Anterior Cingulate Cortex Morphology Predicts Treatment Response to Internet-Based Cognitive Behavioral Therapy for Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Trial
- Altered Static and Dynamic Functional Network Connectivity and Combined Machine Learning in Stroke.Brain topography · 2025Article
- Resting-state fMRI graph theory analysis for predicting selective serotonin reuptake inhibitors treatment response in adolescent major depressive disorder.Frontiers in psychiatry · 2025Article
- Immediate and sustained effects of acupuncture on the default mode network.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Early differences in lassitude predicts outcomes in Stanford Neuromodulation Therapy for difficult to treat depression.Npj mental health research · 2024Article
- Differential modulation of resting-state functional connectivity between amygdala and precuneus after acute physical exertion of varying intensity: indications for a role in affective regulation.Frontiers in human neuroscience · 2024Article
- The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study.Behavioral and brain functions : BBF · 2023Article
- Recognition of Facial Emotion Expressions in Patients with Depressive Disorders: A Functional MRI Study.Tomography (Ann Arbor, Mich.) · 2023Article
- Review: The use of functional magnetic resonance imaging (fMRI) in clinical trials and experimental research studies for depression.Frontiers in neuroimaging · 2023Review
- Altered functional connectivity in first-episode and recurrent depression: A resting-state functional magnetic resonance imaging study.Frontiers in neurology · 2022Article
- Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis.Frontiers in neuroscience · 2022Article
- Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography.Nature biomedical engineering · 2021Article
- Distinct Features of Cerebral Blood Flow and Spontaneous Neural Activity as Integrated Predictors of Early Response to Antidepressants.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Several previous functional magnetic resonance imaging (fMRI) studies have demonstrated the predictive value of brain activity during emotion processing for antidepressant response, with a focus on clinical outcome after 6-8 weeks. However, longitudinal studies emphasize the paramount importance of early symptom improvement for the course of disease in major depressive disorder (MDD). We therefore aimed to assess whether neural activity during the emotion discrimination task (EDT) predicts early antidepressant effects, and how these predictive measures relate to more sustained response. Twenty-three MDD patients were investigated once with ultrahigh-field 7T fMRI and the EDT. Following fMRI, patients received Escitalopram in a flexible dose schema and were assessed with the Hamilton Depression Rating Scale (HAMD) before, and after 2 and 4 weeks of treatment. Deactivation of the precuneus and posterior cingulate cortex (PCC) during the EDT predicted change in HAMD scores after 2 weeks of treatment. Baseline EDT activity was not predictive of HAMD change after 4 weeks of treatment. The precuneus and PCC are integral components of the default mode network (DMN). We show that patients who exhibit stronger DMN suppression during emotion processing are more likely to show antidepressant response after 2 weeks. This is, to our knowledge, the first study to show that DMN activity predicts early antidepressant effects. However, DMN deactivation did not predict response at 4 weeks, suggesting that our finding is representative of early, likely treatment-related, yet unspecific symptom improvement. Regardless, early effects may be harnessed for optimization of treatment regimens and patient care.
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