ArticleBiosensors2017
Composite Hydrogels with Engineered Microdomains for Optical Glucose Sensing at Low Oxygen Conditions.
Article in Biosensors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Engineering Multilayer Poly(ethylene glycol) Hydrogels via Off-Stoichiometry Thiol-Ene Chemistry.ACS applied polymer materials · 2026Article
- Development of an Insertable Enzymatic Sensor TowardsIEEE sensors letters · 2026Article
- NIR Phosphorescent Oxygen Sensors in Natural Hydrogel Matrices.bioRxiv : the preprint server for biology · 2025Article
- Hydrogel Innovations in Biosensing: A New Frontier for Pancreatitis Diagnostics.Bioengineering (Basel, Switzerland) · 2025Review
- Insertable Biomaterial-Based Multianalyte Barcode Sensor toward Continuous Monitoring of Glucose and Oxygen.ACS sensors · 2024Article
- Insertable Glucose Sensor Using a Compact and Cost-Effective Phosphorescence Lifetime Imager and Machine Learning.ACS nano · 2024Article
- Long-Term Evaluation of Inserted Nanocomposite Hydrogel-Based Phosphorescent Oxygen Biosensors: Evolution of Local Tissue Oxygen Levels and Foreign Body Response.ACS applied bio materials · 2024Article
- Glucose biosensors based on Michael addition crosslinked poly(ethylene glycol) hydrogels with chemo-optical sensing microdomains.Journal of materials chemistry. B · 2023Article
- NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring.Biosensors · 2023Article
- Enzymes Encapsulated within Alginate Hydrogels: Bioelectrocatalysis and Electrochemiluminescence Applications.Analytical chemistry · 2022Article
- Monte Carlo method for assessment of a multimodal insertable biosensor.Journal of biomedical optics · 2022Article
- Review
- Glucose Sensing in Human Whole Blood Based on Near-Infrared Phosphors and Outlier Treatment with the Programming Language "R".ACS omega · 2022Article
- Multifunctional Polymeric Nanogels for Biomedical Applications.Gels (Basel, Switzerland) · 2021Review
- Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing.Sensors (Basel, Switzerland) · 2021Review
- A Versatile Multichannel Instrument for Measurement of Ratiometric Fluorescence Intensity and Phosphorescence Lifetime.IEEE access : practical innovations, open solutions · 2021Article
- Enzyme functionalized microgels enable precise regulation of dissolved oxygen and anaerobe culture.Materials today. Bio · 2021Article
- Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments.Frontiers in chemistry · 2021Review
- Porphyrins as Colorimetric and Photometric Biosensors in Modern Bioanalytical Systems.Chembiochem : a European journal of chemical biology · 2020Review
- Hydrogel Actuators and Sensors for Biomedical Soft Robots: Brief Overview with Impending Challenges.Biomimetics (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
There is a growing need for advanced tools that enable frequent monitoring of biomarkers for precision medicine. In this work, we present a composite hydrogel-based system providing real-time optical bioanalyte monitoring. The responsive material, alginate-in-alginate (AnA), is comprised of an alginate hydrogel with embedded bioactive, nanofilm-coated phosphorescent microdomains; palladium tetracarboxyphenylporphyrin serves as an optical indicator, glucose oxidase as a model enzyme, and layer-by-layer deposited polyelectrolyte multilayers (PEMs) as the diffusion barrier. Glutaraldehyde crosslinking of the nanofilms resulted in a dramatic reduction in glucose diffusion (179%) while oxygen transport was not significantly affected. The responses of the AnA hydrogels to step changes of glucose at both ambient and physiological oxygen levels were evaluated, revealing controlled tuning of sensitivity and dynamic range. Stability, assessed by alternately exposing the responsive AnA hydrogels to extremely high and zero glucose concentrations, resulted in no significant difference in the response over 20 cycles. These AnA hydrogels represent an attractive approach to biosensing based on biocompatible materials that may be used as minimally-invasive, implantable devices capable of optical interrogation. The model glucose-responsive composite material studied in this work will serve as a template that can be translated for sensing additional analytes (e.g., lactate, urea, pyruvate, cholesterol) and can be used for monitoring other chronic conditions.
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Registered trials
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