ArticleMolecules (Basel, Switzerland)2017
Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides.
Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- Antibacterial and Anticandidal Activity of the Nanostructural Composite of a Spirothiazolidine-Derivative Assembled on Silver Nanoparticles.Molecules (Basel, Switzerland) · 2024Article
- Green synthesis, biological and molecular docking of some novel sulfonamide thiadiazole derivatives as potential insecticidal against Spodoptera littoralis.Scientific reports · 2023Article
- Design, Synthesis, and Antiproliferative Activity of Novel Neocryptolepine-Rhodanine Hybrids.Molecules (Basel, Switzerland) · 2022Article
- Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR.Journal of enzyme inhibition and medicinal chemistry · 2021Article
- Synthesis and Preliminary Anticancer Activity Assessment of N-Glycosides of 2-Amino-1,3,4-thiadiazoles.Molecules (Basel, Switzerland) · 2021Article
- Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity.Molecules (Basel, Switzerland) · 2021Article
- Promising Antidiabetic and Antimicrobial Agents Based on Fused Pyrimidine Derivatives: Molecular Modeling and Biological Evaluation with Histopathological Effect.Molecules (Basel, Switzerland) · 2021Article
- Evaluation of antioxidant and anticancer activity of crude extract and different fractions of Chlorella vulgaris axenic culture grown under various concentrations of copper ions.BMC complementary medicine and therapies · 2021Article
- 1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents.Frontiers in chemistry · 2021Review
- Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives-A Review.Molecules (Basel, Switzerland) · 2020Review
- Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes.Molecules (Basel, Switzerland) · 2020Article
- Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues.Molecules (Basel, Switzerland) · 2020Article
- One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1Molecules (Basel, Switzerland) · 2020Article
- Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-ThiadiazoleMolecules (Basel, Switzerland) · 2019Article
- Development of a Novel Series of Anticancer and Antidiabetic: Spirothiazolidines Analogs.Molecules (Basel, Switzerland) · 2019Article
- Synthesis and biological evaluation of 4-(1RSC advances · 2019Article
- Synthesis and evaluation of novel spiro derivatives for pyrrolopyrimidines as anti-hyperglycemia promising compounds.Journal of enzyme inhibition and medicinal chemistry · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New 1-thia-azaspiro[4.5]decane derivatives, their derived thiazolopyrimidine and 1,3,4-thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized (1,3,4-thiadiazolyl)thiaazaspiro[4.5]decane and thiazolopyrimidinethione compounds were synthesized by glycosylation reactions using acetylated glycosyl bromides. The anticancer activity of synthesized compounds was studied against the cell culture of HepG-2 (human liver hepatocellular carcinoma), PC-3 (human prostate adenocarcinoma) and HCT116 (human colorectal carcinoma) cell lines and a number of compounds showed moderate to high inhibition activities.
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