Evidence map›Paper›PMID 28117674›Full record

ArticleInternational journal of molecular sciences2017

Metabolic Response of Human Osteoarthritic Cartilage to Biochemically Characterized Collagen Hydrolysates.

Saskia Schadow, Viktor S Simons, Guenter Lochnit, Jens Kordelle, Zuzana Gazova, Hans-Christian Siebert, Juergen Steinmeyer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

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  7. Evaluation of the Efficacy and Safety of CollaSel PROJournal of clinical medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Saskia SchadowLaboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, Paul-Meimberg-Str. 3, 35392 Giessen, Germany. saskia.schadow@meckit.de.
Viktor S SimonsLaboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, Paul-Meimberg-Str. 3, 35392 Giessen, Germany. Viktor.S.Simons@med.uni-giessen.de.
Guenter LochnitProtein Analytics, Department of Biochemistry, Faculty of Medicine, Justus Liebig University Giessen, Friedrichstr. 24, 35392 Giessen, Germany. Guenter.Lochnit@biochemie.med.uni-giessen.de.
Jens KordelleLaboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, Paul-Meimberg-Str. 3, 35392 Giessen, Germany. jens.kordelle@ekm-gi.de.
Zuzana GazovaInstitute of Experimental Physics, Department of Biophysics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia. gazova@saske.sk.
Hans-Christian SiebertRI-B-NT Research Institute of Bioinformatics and Nanotechnology, Franziusallee 177, 24148 Kiel, Germany. hcsiebert@aol.com.
Juergen SteinmeyerLaboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, Paul-Meimberg-Str. 3, 35392 Giessen, Germany. Juergen.Steinmeyer@ortho.med.uni-giessen.de.
Justus-Liebig-Universität Gießen · DEClinical Research Center Kiel · DESlovak Academy of Sciences · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most frequent disease of the locomotor system is osteoarthritis (OA), which, as a chronic joint disease, might benefit more from nutrition than acute illnesses. Collagen hydrolysates (CHs) are peptidic mixtures that are often used as nutraceuticals for OA. Three CHs were characterized biochemically and pharmacologically. Our biophysical (MALDI-TOF-MS, NMR, AFM) and fluorescence assays revealed marked differences between CHs of fish (Peptan

Indexed as

AnimalsCartilage, ArticularCell SurvivalChondrocytesCollagenDose-Response Relationship, DrugEndopeptidasesFishesHumansInterleukin-6Magnetic Resonance SpectroscopyMatrix MetalloproteinasesMicroscopy, Atomic ForceOsteoarthritisProtein HydrolysatesProteoglycansaggrecanaseCollagenEndopeptidasesInterleukin-6Matrix MetalloproteinasesProtein HydrolysatesProteoglycansReceptors, Interleukin-6Tissue Inhibitor of MetalloproteinasesADAMTScartilagecollagen hydrolysateIL6, MALDI-TOFMMPMobiforte®osteoarthritisPeptan® FTIMP

Identifiers

PMID28117674
PMCPMC5297837
OpenAlexW2572199266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.