ArticleObesity (Silver Spring, Md.)2017
Brown adipose tissue does not seem to mediate metabolic adaptation to overfeeding in men.
Article in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Effects of Nutrition/Diet on Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Infrared Thermography for Estimating Supraclavicular Skin Temperature and BAT Activity in Humans: A Systematic Review.Obesity (Silver Spring, Md.) · 2019Pooled it
- Trial
- Investigation of the relationship between BAT activity and thermal comfort under short-term cold temperature exposure.Scientific reports · 2025Article
- Imaging Brown Adipose Tissue: Current State and Future Perspective.Theranostics · 2025Review
- Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarizedCommunications medicine · 2023Article
- Physiological protection against weight gain: evidence from overfeeding studies and future directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Metabolic Factors Determining the Susceptibility to Weight Gain: Current Evidence.Current obesity reports · 2020Review
- Brown adipose tissue volume and 18F-fluorodeoxyglucose uptake are not associated with energy intake in young human adults.The American journal of clinical nutrition · 2020Article
- Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders.International journal of obesity (2005) · 2019Article
- Is activation of human brown adipose tissue a viable target for weight management?American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Norepinephrine and T4 Are Predictors of Fat Mass Gain in Humans With Cold-Induced Brown Adipose Tissue Activation.The Journal of clinical endocrinology and metabolism · 2018Article
- The use of infrared thermography in the measurement and characterization of brown adipose tissue activation.Temperature (Austin, Tex.) · 2018Review
- Brown Adipose Tissue: an Update on Recent Findings.Current obesity reports · 2017Review
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveBrown adipose tissue (BAT) generates heat in response to cold, and low BAT activity has been linked to obesity. However, recent studies were inconclusive as to whether BAT is involved in diet-induced thermogenesis and mitigates weight gain from prolonged overeating. Therefore, this study investigated whether BAT activity is related to metabolic adaptation arising from 8 weeks of overfeeding in humans.
methodsFourteen men (aged 24 ± 3 years, BMI 24.5 ± 1.6 kg/m
resultsAt the end of 8 weeks of overfeeding, metabolic adaptation-defined as the percent increase in sleeping energy expenditure beyond that expected from weight gain-rose from -0.9 ± 3.9% to 4.7 ± 5.6% (P = 0.001). However, BAT thermal activity was unchanged (P = 0.81). Moreover, BAT thermal activity did not correlate with the degree of metabolic adaptation (P = 0.32) or with the change in body weight (P = 0.51).
conclusionsBAT thermal activity does not change in response to overfeeding, nor does it correlate with adaptive thermogenesis. Our data suggest that BAT does not mediate metabolic adaptation to overeating in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.