ArticleScientific reports2017
Safety assessment of Staphylococcus phages of the family Myoviridae based on complete genome sequences.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Phenotypic and Genotypic Characterization of Novel Polyvalent Bacteriophages With PotentFrontiers in cellular and infection microbiology · 2021Trial
- Phage as control strategy against the foodborne pathogen, Bacillus cereus.Archives of microbiology · 2026Review
- Lifestyle shapes genome architecture and codon usage bias inFrontiers in microbiology · 2026Article
- Genomic and proteomic characterization of four novel Schitoviridae family phages targeting uropathogenic Escherichia coli strain.Virology journal · 2025Article
- Oral bacteriophages and their potential as adjunctive treatments for periodontitis: a narrative review.Journal of oral microbiology · 2025Review
- Biological characterization and genomic analysis of a novel methicillin-resistantMicrobiology spectrum · 2024Article
- The Post-Antibiotic Era: A New Dawn for Bacteriophages.Biology · 2023Review
- Genomic Characterization and Antimicrobial Susceptibility of Dromedary-AssociatedApplied and environmental microbiology · 2022Article
- Combination Treatment for Inhibition of the Growth ofAntibiotics (Basel, Switzerland) · 2022Article
- Characterization of a New and Efficient Polyvalent Phage InfectingMicroorganisms · 2021Article
- Bi- and Multi-directional Gene Transfer in the Natural Populations of Polyvalent Bacteriophages, and Their Host Species Spectrum Representing Foodborne Versus Other Human and/or Animal Pathogens.Food and environmental virology · 2021Article
- εPharmaceuticals (Basel, Switzerland) · 2021Article
- JD419, aFrontiers in microbiology · 2021Article
- Identification and Characterization of the CRISPR/Cas System inFrontiers in microbiology · 2021Article
- Article
- VirulentFrontiers in microbiology · 2021Article
- Antibiotic Resistance: One Health One World Outlook.Frontiers in cellular and infection microbiology · 2021Review
- AViruses · 2020Article
- BioprospectingViruses · 2020Article
- Exploring the whole standard operating procedure for phage therapy in clinical practice.Journal of translational medicine · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus phages of the Myoviridae family have a wide host range and potential applications in phage therapy. In this report, safety assessments of these phages were conducted based on their complete genome sequences. The complete genomes of Staphylococcus phages of the Myoviridae family were analyzed, and the Open Reading Frame (ORFs) were compared with a pool of virulence and antibiotic resistance genes using the BLAST algorithm. In addition, the lifestyle of the phages (virulent or temperate) was also confirmed using PHACTS. The results showed that all phages were lytic and did not contain resistance or virulence genes based on bioinformatic analyses, excluding the possibility that they could be vectors for the dissemination of these undesirable genes. These findings suggest that the phages are safe at the genome level. The SceD-like transglycosylase, which is a biomarker for vancomycin-intermediate strains, was widely distributed in the phage genomes. Approximately 70% of the ORFs encoded in the phage genomes have unknown functions; therefore, their roles in the antibiotic resistance and virulence of Staphylococcus aureus are still unknown and require consideration before use in phage therapy.
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