ArticleThe American journal of gastroenterology2017
A Prospective Study of Smoking and Risk of Synchronous Colorectal Cancers.
Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Retinal Vascular Features and Risk of Colorectal Cancer Incidence and Mortality: A Population-Based Cohort Study.Ophthalmology and therapy · 2026Article
- Smoking metabolic signature modifies the risk of colorectal cancer and interacts with genetic susceptibility: a large-scale prospective cohort study.BMC cancer · 2026Article
- Synergistic Interactions Between Gut and Intratumoral Microbiota: A New Perspective on the Oncogenesis and Treatment of Colorectal Cancer.Digestive diseases and sciences · 2026Review
- Rare synchronous colorectal carcinoma with three pathological subtypes: A case report and review of the literature.World journal of clinical cases · 2023Article
- Developing prognostic nomograms to predict overall survival and cancer-specific survival in synchronous multiple primary colorectal cancer based on the SEER database.Journal of cancer research and clinical oncology · 2023Article
- Article
- Association Between Smoking and Molecular Subtypes of Colorectal Cancer.JNCI cancer spectrum · 2021Article
- Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes.JNCI cancer spectrum · 2021Article
- Common habitual behaviors and synchronous colorectal cancer risk: a retrospective case-control study.International journal of colorectal disease · 2019Article
- The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma.BMC medical genetics · 2019Article
- Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells.Journal of the National Cancer Institute · 2019Article
- Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas.Gastroenterology · 2018Article
- Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesCigarette smoking has been linked to somatic genetic and epigenetic aberrations, including CpG island methylator phenotype (CIMP)-high, microsatellite instability (MSI)-high and BRAF mutation. These molecular features have been associated with synchronous primary colorectal cancers (CRCs). Thus, we examined the hypothesis that smoking might be associated with the risk of synchronous CRCs.
methodsWithin the Health Professionals Follow-up Study and Nurses' Health Study, we examined the relationship of smoking and incidence of CRC according to tumor synchronicity, using duplication-method Cox proportional hazards regression analysis.
resultsWe confirmed 1,981 solitary CRC and 45 synchronous CRC cases during follow-up of 134,305 individuals. CRC risk associated with smoking differed significantly by tumor synchronicity status (P
conclusionsSmoking is associated with an elevated risk of synchronous CRCs. Our data support a model where smoking contributes to an etiologic field effect that favors these somatic molecular alterations and the development of multiple primary tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.