Evidence map›Paper›PMID 28117332›Full record

SynthesisSpinal cord2017

Animal models of spinal cord injury: a systematic review.

M Sharif-Alhoseini, M Khormali, M Rezaei, M Safdarian, A Hajighadery, M M Khalatbari, M Safdarian, S Meknatkhah, M Rezvan, M Chalangari and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Spinal cord, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  11. Histological Findings After Aortic Cross-Clamping in Preclinical Animal Models.Journal of neuropathology and experimental neurology · 2021
    Pooled it
  12. Pooled it
  13. Review
  14. Visible light, oxidative stress, and reproduction: The protective role of melatonin.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Review
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  18. Transcriptomics Insights into Spinal Cord Injury for Therapy Development.International journal of molecular sciences · 2026
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  20. Article

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M Sharif-AlhoseiniSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M KhormaliSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M RezaeiSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M SafdarianSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
A HajighaderySina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M M KhalatbariSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M SafdarianSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
S MeknatkhahLaboratory of Neuro-Organic Chemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.
M RezvanSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M ChalangariSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
P DerakhshanSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
V Rahimi-MovagharSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designPRISMA-guided systematic review.

objectivesTo provide a comprehensive framework of the current animal models for investigating spinal cord injury (SCI) and categorize them based on the aims, patterns and levels of injury, and outcome measurements as well as animal species.

settingSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

methodsAn electronic search of the Medline database for literature describing animal models of SCI was performed on 1 January 2016 using the following keywords: 'spinal cord injuries' and 'animal models'. The search retrieved 2870 articles. Reviews and non-original articles were excluded. Data extraction was independently performed by two reviewers.

resultsAmong the 2209 included studies, testing the effects of drug's or growth factor's interventions was the most common aim (36.6%) followed by surveying pathophysiologic changes (30.2%). The most common spinal region involved was thoracic (81%). Contusion was the most common pattern of injury (41%) followed by transection (32.5%) and compression (19.4%). The most common species involved in animal models of SCI was the rat (72.4%). Two or more types of outcome assessments were used in the majority of the studies, and the most common assessment method was biological plus behavioral (50.8%).

conclusionsPrior to choosing an animal model, the objectives of the proposed study must precisely be defined. Contusion and compression models better simulate the biomechanics and neuropathology of human injury, whereas transection models are valuable to study anatomic regeneration. Rodents are the most common and probably best-suited species for preliminary SCI studies.

Indexed as

Disease Models, AnimalSpinal Cord InjuriesAnimalsHumans

Identifiers

PMID28117332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.