ArticleMolecular plant pathology2018
Involvement of ralfuranones in the quorum sensing signalling pathway and virulence of Ralstonia solanacearum strain OE1-1.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 55 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Contribution of a Novel TetR/AcrR Family Transcriptional Regulator RalT of Ralstonia pseudosolanacearum Strain OE1-1 to the Fine-Tuning of Its Virulence.MicrobiologyOpen · 2026Article
- Article
- The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes inMicrobiology spectrum · 2025Article
- Root exudate monosaccharides modulate the pathogenicity ofFrontiers in microbiology · 2025Article
- Strategies utilized by plants to defend againstFrontiers in plant science · 2025Review
- Navigating the signaling landscape of Ralstonia solanacearum: a study of bacterial two-component systems.World journal of microbiology & biotechnology · 2024Review
- The transcription regulator ChpA affects the global transcriptome including quorum sensing-dependent genes in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2023Article
- β-1,4-Cellobiohydrolase is involved in full expression of phcA, contributing to the feedback loop in quorum sensing of Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2023Article
- Article
- Biocomputational Assessment of Natural Compounds as a Potent Inhibitor to Quorum Sensors inMolecules (Basel, Switzerland) · 2022Article
- PhcQ mainly contributes to the regulation of quorum sensing-dependent genes, in which PhcR is partially involved, in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2021Article
- Light modulates important physiological features of Ralstonia pseudosolanacearum during the colonization of tomato plants.Scientific reports · 2021Article
- The putative sensor histidine kinase PhcK is required for the full expression of phcA encoding the global transcriptional regulator to drive the quorum-sensing circuit of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2020Article
- Expression of Ralstonia solanacearum type III secretion system is dependent on a novel type 4 pili (T4P) assembly protein (TapV) but is T4P independent.Molecular plant pathology · 2020Article
- Review
- Article
- Effect of the luxI/R gene on AHL-signaling molecules and QS regulatory mechanism in Hafnia alvei H4.AMB Express · 2019Article
- Major exopolysaccharide, EPS I, is associated with the feedback loop in the quorum sensing of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2019Article
- Bioorganic chemistry of signaling molecules in microbial communication.Journal of pesticide science · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The soil-borne, plant-pathogenic Ralstonia solanacearum strain OE1-1 produces and secretes methyl 3-hydroxymyristate (3-OH MAME) as a quorum sensing (QS) signal, which contributes to its virulence. A global virulence regulator, PhcA, functioning through the QS system, positively regulates the expression of ralA, which encodes furanone synthase, to produce aryl-furanone secondary metabolites, ralfuranones. A ralfuranone-deficient mutant (ΔralA) is weakly virulent when directly inoculated into tomato xylem vessels. To investigate the functions of ralfuranones, we analysed R. solanacearum transcriptome data generated by RNA sequencing technology. ΔralA expressed phcB, which is associated with 3-OH MAME production, and phcA at levels similar to those in strain OE1-1. In addition, ΔralA exhibited down-regulated expression of more than 90% of the QS positively regulated genes, and up-regulated expression of more than 75% of the QS negatively regulated genes. These results suggest that ralfuranones affect the QS feedback loop. Ralfuranone supplementation restored the ability of ΔralA cells to aggregate. In addition, ralfuranones A and B restored the swimming motility of ΔralA to wild-type levels. However, the application of exogenous ralfuranones did not affect the production of the major exopolysaccharide, EPS I, in ΔralA. Quantitative real-time polymerase chain reaction assays revealed that the deletion of ralA results in the down-regulated expression of vsrAD and vsrBC, which encode a sensor kinase and a response regulator, respectively, in the two-component regulatory systems that influence EPS I production. The application of ralfuranone B restored the expression of these two genes. Overall, our findings indicate that integrated signalling via ralfuranones influences the QS and virulence of R. solanacearum.
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