ArticleJournal of clinical laboratory analysis2017
Clinical phenotypes and the biological parameters of Congolese patients suffering from sickle cell anemia: A first report from Central Africa.
Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Genetic Modulators of Diversity in the Biological Expression of Sickle Cell Anemia in Patients from Democratic Republic of Congo: Role of βs-globin Haplotypes.Mediterranean journal of hematology and infectious diseases · 2025Article
- Article
- Rehabilitation: a key service, yet highly underused, in the management of young patients with sickle cell disease after stroke in DR of Congo.Frontiers in neurology · 2023Article
- Value of DNA testing in the diagnosis of sickle-cell anemia in childhood in an environment with a high prevalence of other causes of anemia.Journal of clinical laboratory analysis · 2022Article
- DNA testing for sickle cell anemia in Africa: Implementation choices for the Democratic Republic of Congo.Journal of clinical laboratory analysis · 2022Article
- Clinical and laboratory characterization of adult sickle cell anemia patients in Kinshasa.PloS one · 2022Article
- Nutritional perspectives on sickle cell disease in Africa: a systematic review.BMC nutrition · 2021Article
- Homozygous Deletion Alpha-Thalassemia and Hereditary Persistence of Fetal Hemoglobin, Two Genetic Factors Predictive the Reduction of Morbidity and Mortality During Pregnancy in Sickle Cell Patients. A Report from the Democratic Republic of Congo.Mediterranean journal of hematology and infectious diseases · 2019Article
- Clinical phenotypes and the biological parameters of Congolese patients suffering from sickle cell anemia: A first report from Central Africa.Journal of clinical laboratory analysis · 2017Article
- Sickle cell anemia: hierarchical cluster analysis and clinical profile in a cohort in Brazil.Hematology, transfusion and cell therapyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe influence of phenotype on the clinical course and laboratory features of sickle cell anemia (SCA) is rarely described in sub-Saharan Africa.
methodsA cross-sectional study was conducted in Kinshasa. A clinical phenotype score was built up. The following definitions were applied: asymptomatic clinical phenotype (ACP; score≤5), moderate clinical phenotype (MCP; score between 6 and 15), and severe clinical phenotype (SCP; score≥16). ANOVA test were used to compare differences among categorical variables.
resultsWe have studied 140 patients. The mean body mass index (BMI) value of three groups was lower (<25 kg/m
conclusionIn our study, fetal hemoglobin has an influence on the clinical severity and the biological parameters of SCA. The study provides data concerning the sickle cell anemia clinical and biological variability in our midst.
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