Evidence map›Paper›PMID 28116655›Full record

ArticleDrug delivery and translational research2018

Synthesis and characterization of chitosan-grafted-polycaprolactone micelles for modulate intestinal paclitaxel delivery.

Andreia Almeida, Daniella Silva, Virginia Gonçalves, Bruno Sarmento

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. An overview of chitosan and its application in infectious diseases.Drug delivery and translational research · 2021
    Review
  5. Article
  6. Article
  7. Pharmaceutics · 2018
    Article
  8. Novel drug delivery systems, devices, and fabrication methods.Drug delivery and translational research · 2018
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Andreia AlmeidaInstituto de Investigação e Inovação em Saúde (i3S) and Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Rua Alfredo Allen, 208, 4200-393, Porto, Portugal.
Daniella SilvaInstituto de Química de São Carlos, Universidade de São Paulo, Avenida Trabalhador São-Carlense, São Carlos, SP, 400-13560-970, Brazil.
Virginia GonçalvesCESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, 4585-116, Gandra, Portugal.
Bruno SarmentoInstituto de Investigação e Inovação em Saúde (i3S) and Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Rua Alfredo Allen, 208, 4200-393, Porto, Portugal. bruno.sarmento@ineb.up.pt.
Cooperativa de Ensino Superior Politécnico e Universitário · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTInstituto de Investigação e Formação Avançada em Ciências e Tecnologias da SaúdeUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, self-assembled amphiphilic micelles based on chitosan (CS) and polycaprolactone (PCL) were produced and used as carriers of paclitaxel (PTX) to improve its intestinal pharmacokinetic profile. Chitosan-grafted-polycaprolactone (CS-g-PCL) was synthesized through a carbodiimide reaction by amidation and confirmed by Fourier transform infrared spectroscopy (FTIR), hydrogen nuclear magnetic resonance analysis (

Indexed as

MicellesAntineoplastic Agents, PhytogenicCaco-2 CellsCell SurvivalChitosanDrug CarriersHT29 CellsHumansIntestinal MucosaPaclitaxelPolyestersAntineoplastic Agents, PhytogenicChitosanDrug CarriersMicellesPaclitaxelpolycaprolactonePolyestersChitosanDrug deliveryMicellesPaclitaxelPolycaprolactone

Identifiers

PMID28116655
OpenAlexW2582664802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.