ArticleScience advances2017
ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.
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Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Cumulative disruption of regulatory genes precedes whole-chromosome gains in acute myeloid leukemia.Leukemia · 2026Article
- Article
- Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency.Nature communications · 2025Article
- A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3.BMC medical genomics · 2024Article
- Cohesin mutations in acute myeloid leukemia.Leukemia · 2024Review
- Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models.The Journal of clinical investigation · 2024Article
- A reappraisal of ASXL1 mutation sites and the cohesin-binding motif in myeloid disease.Blood cancer journal · 2023Article
- Epigenetic regulation by ASXL1 in myeloid malignancies.International journal of hematology · 2023Review
- Clinical and prognostic impact of STAG2 mutations in myeloid neoplasms: the Mayo Clinic experience.Blood advances · 2023Article
- ASXL1/2 mutations and myeloid malignancies.Journal of hematology & oncology · 2022Review
- DNA methylation signature associated with Bohring-Opitz syndrome: a new tool for functional classification of variants in ASXL genes.European journal of human genetics : EJHG · 2022Article
- SMC1A regulated by KIAA1429 in m6A-independent manner promotes EMT progress in breast cancer.Molecular therapy. Nucleic acids · 2022Article
- The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia.Haematologica · 2021Article
- Review
- A cohesive look at leukemogenesis: The cohesin complex and other driving mutations in AML.Neoplasia (New York, N.Y.) · 2021Review
- Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.Frontiers in immunology · 2021Article
- Epigenetic Mechanisms in Leukemias and Lymphomas.Cold Spring Harbor perspectives in medicine · 2020Review
- Integrated analysis of a compendium of RNA-Seq datasets for splicing factors.Scientific data · 2020Article
- Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.Cancer discovery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 1 country.
Zhaomin LiSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Peng ZhangSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Aimin YanSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Zhengyu GuoDepartment of Electrical and Computer Engineering and TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX 77843, USA.
Yuguang BanSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Jin LiDepartment of Electrical and Computer Engineering and TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX 77843, USA.
Shi ChenSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Hui YangSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Yongzheng HeHerman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jianping LiSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ying GuoSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Wen ZhangSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ehsan HajiramezanaliDepartment of Electrical and Computer Engineering and TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX 77843, USA.
Huangda AnSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Darlene FajardoSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
J William HarbourSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Yijun RuanThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.
Stephen D NimerSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Peng YuDepartment of Electrical and Computer Engineering and TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX 77843, USA.
Xi ChenSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Mingjiang XuSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Feng-Chun YangSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0001-8524-4095
University of Miami · USTexas A&M University System · USIndiana University School of MedicineJackson Laboratory · US
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MComprehensive Mapping of Long-Range Chromatin Interactions in Humanand Mouse GenomesUM1HG009409 · NHGRI · JACKSON LABORATORY · PI LEE, CHARLES · 2017 to 2021
$9.8MTHE GENETICS OF OCULAR MELANOMAR01CA161870 · NCI · WASHINGTON UNIVERSITY · PI BOWCOCK, ANNE MARY · 2011 to 2024
$5.5MTargeting p300 and lysine acetylation in AMLR01CA166835 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2012 to 2026
$4.6MNucleome Positioning System for Spatiotemporal Genome Organization and RegulationU54DK107967 · NIDDK · JACKSON LABORATORY · PI WEI, CHIA-LIN · 2015 to 2019
$3.6MRole of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01CA172408 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2024
$3.4MCharacterization of RNA-Chromatin Interactome by RNA-DNA Ligation and SequencingR01CA186714 · NCI · JACKSON LABORATORY · PI RUAN, YIJUN · 2014 to 2016
$2.2MNo-nonsense approach to treat myeloid malignancies with ASXL1 nonsense mutationsR21CA185751 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2015
$370kWorkshop on Chromatin Interaction Analysis using Paired-End Tag SequencingR25HG007631 · NHGRI · JACKSON LABORATORY · PI RUAN, YIJUN · 2015 to 2017
$157kNCI NIH HHS P30 CA034196NCI NIH HHS R01 CA161870NCI NIH HHS R01 CA166835NCI NIH HHS R01 CA172408NCI NIH HHS R01 CA186714NCI NIH HHS R21 CA185751NHGRI NIH HHS R25 HG007631NHGRI NIH HHS UM1 HG009409NIDDK NIH HHS U54 DK107967
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCell Cycle ProteinsChromatidsChromosomal Proteins, Non-HistoneChromosome SegregationCohesinsDNA-Binding ProteinsGene Expression RegulationHematopoiesisMiceMice, KnockoutNuclear ProteinsPhosphoproteinsRepressor ProteinsTelophaseAsxl1 protein, mouseCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsDNA-Binding ProteinsNuclear ProteinsPhosphoproteinsRad21 protein, mouseRepressor ProteinsASXL1cohesin complexgene regulationhematopoiesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.