ArticleMolecular genetics & genomic medicine2017
Sherpas share genetic variations with Tibetans for high-altitude adaptation.
Article in Molecular genetics & genomic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High-Altitude Adaptive Genetic Variants in Sherpa Highlanders.Annals of human genetics · 2026Article
- Advances in Understanding Adaptive Hemoglobin Concentration at High Altitude.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.Cancer discovery · 2025Article
- Association between single nucleotide polymorphisms inFrontiers in genetics · 2025Article
- Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differential splenic responses to hyperoxic breathing at high altitude in Sherpa and lowlanders.Experimental physiology · 2024Article
- Novel insight into the genetic signatures of altitude adaptation related body composition in Tibetans.Frontiers in public health · 2024Article
- The Increase in Hemoglobin Concentration With Altitude Differs Between World Regions and Is Less in Children Than in Adults.HemaSphere · 2023Article
- Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude.Experimental physiology · 2023Article
- The impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication.Frontiers in physiology · 2022Article
- Neural network correlates of high-altitude adaptive genetic variants in Tibetans: A pilot, exploratory study.Human brain mapping · 2020Article
- Genetic Analysis ofParkinson's disease · 2020Article
- Population History and Altitude-Related Adaptation in the Sherpa.Frontiers in physiology · 2019Review
- Endothelial dysfunction assessment by flow-mediated dilation in a high-altitude population.Vascular health and risk management · 2017Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSherpas, a highlander population living in Khumbu region of Nepal, are well known for their superior climbing ability in Himalayas. However, the genetic basis of their adaptation to high-altitude environments remains elusive.
methodsWe collected DNA samples of 582 Sherpas from Nepal and Tibetan Autonomous Region of China, and we measured their hemoglobin levels and degrees of blood oxygen saturation. We genotyped 29
resultsWe found similar allele frequencies on the tested 32 variants of these genes in Sherpas and Tibetans. Sherpa individuals carrying the derived alleles of
conclusionThe shared sequence variants and hemoglobin trait between Sherpas and Tibetans indicate a shared genetic basis for high-altitude adaptation, consistent with the proposal that Sherpas are in fact a recently derived population from Tibetans and they inherited adaptive variants for high-altitude adaptation from their Tibetan ancestors.
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