Evidence map›Paper›PMID 28116308›Full record

ArticleBioMed research international2017

Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway.

Wei Cai, Xi-Mei Duan, Ying Liu, Jiao Yu, Yun-Liang Tang, Ze-Lin Liu, Shan Jiang, Chun-Ping Zhang, Jian-Ying Liu, Ji-Xiong Xu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 2 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 2 syntheses or guidelines pooled it, 175 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. HMGB1 as a danger signal in vascular remodeling.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Review
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  8. The role of HMGB1 in vascular endothelial cells.Apoptosis : an international journal on programmed cell death · 2026
    Review
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  10. Article
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  15. Article
  16. Review
  17. Observational
  18. Article
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wei CaiDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; Department of Medical Genetics and Cell Biology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, China.
Xi-Mei DuanDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; Department of Endocrinology and Metabolism, People's Hospital of Shangrao City, Shangrao, Jiangxi 334600, China.
Ying LiuDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Jiao YuDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Yun-Liang TangDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Ze-Lin LiuDepartment of Endocrinology and Metabolism, Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330003, China.
Shan JiangDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Chun-Ping ZhangDepartment of Medical Genetics and Cell Biology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, China.
Jian-Ying LiuDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Ji-Xiong XuDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.ORCID 0000-0002-4947-3576
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uric acid (UA) is a risk factor for endothelial dysfunction, a process in which inflammation may play an important role. UA increases high mobility group box chromosomal protein 1 (HMGB1) expression and extracellular release in endothelial cells. HMGB1 is an inflammatory cytokine that interacts with the receptor for advanced glycation end products (RAGE), inducing an oxidative stress and inflammatory response, which leads to endothelial dysfunction. In this study, human umbilical vein endothelial cells (HUVECs) were incubated with a high concentration of UA (20 mg/dL) after which endothelial function and the expression of HMGB1, RAGE, nuclear factor kappa B (NF-

Indexed as

Gene Expression Regulation, EnzymologicCell AdhesionCytokinesEndothelium, VascularEnzyme-Linked Immunosorbent AssayHMGB1 ProteinHumansHuman Umbilical Vein Endothelial CellsInflammationNF-kappa BNitric OxideNitric Oxide Synthase Type IIIOxidative StressReceptor for Advanced Glycation End ProductsSignal TransductionUric AcidAGER protein, humanCytokinesHMGB1 ProteinHMGB1 protein, humanNF-kappa BNitric OxideNitric Oxide Synthase Type IIINOS3 protein, humanReceptor for Advanced Glycation End ProductsUric Acid

Identifiers

PMID28116308
PMCPMC5237466
OpenAlexW2564213835

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.