Evidence map›Paper›PMID 28116236›Full record

ArticleNeuroImage. Clinical2017

The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the

Emma M Devenney, Ramon Landin-Romero, Muireann Irish, Michael Hornberger, Eneida Mioshi, Glenda M Halliday, Matthew C Kiernan, John R Hodges

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Psychiatric disorders in amyotrophic lateral sclerosis: a short note.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  5. Brain metabolic connectivity in ALS due to C9ORF72 hexanucleotide expansion: a [European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Observational
  7. Article
  8. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Emma M DevenneyNeuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia; University of New South Wales, Sydney, NSW 2031, Australia; Brain and Mind Research Institute, Camperdown, Sydney, NSW 2050, Australia; ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW 2109, Australia.
Ramon Landin-RomeroNeuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia; University of New South Wales, Sydney, NSW 2031, Australia; ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW 2109, Australia.
Muireann IrishNeuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia; University of New South Wales, Sydney, NSW 2031, Australia; ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW 2109, Australia.
Michael HornbergerUniversity of East Anglia, Norwich NR4 7TJ, United Kingdom.
Eneida MioshiUniversity of East Anglia, Norwich NR4 7TJ, United Kingdom.
Glenda M HallidayNeuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia; University of New South Wales, Sydney, NSW 2031, Australia.
Matthew C KiernanNeuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia; University of New South Wales, Sydney, NSW 2031, Australia; Brain and Mind Research Institute, Camperdown, Sydney, NSW 2050, Australia.
John R HodgesNeuroscience Research Australia, Barker Street, Sydney, NSW 2031, Australia; University of New South Wales, Sydney, NSW 2031, Australia; ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW 2109, Australia.
ARC Centre of Excellence in Cognition and its Disorders · AUUniversity of East Anglia · GBUNSW Sydney · AUMacquarie University · AUNeuroscience Research Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis present study aims to address the gap in the literature regarding the severity and underlying neural correlates of psychotic symptoms in frontotemporal dementia with and without the

methodsFifty-six patients with behavioural variant frontotemporal dementia (20 with concomitant amyotrophic lateral sclerosis) and 23 healthy controls underwent neuropsychological assessments, detailed clinical interview for assessment of psychosis symptoms, brain MRI and genetic testing. Carers underwent a clinical interview based upon the neuropsychiatric inventory. Patients were assessed at ForeFront, the Frontotemporal Dementia Research Group at Neuroscience Research Australia or at the Brain and Mind Centre, between January 2008 and December 2013. An index of psychosis was calculated, taking into account the degree and severity of psychosis in each case. Voxel-based morphometry analyses were used to explore relationships between the psychosis index and grey matter changes.

resultsThirty-four percent of frontotemporal dementia patients showed psychotic features.

conclusionsThis study underlines the need to consider and assess for psychotic symptoms in the frontotemporal dementia-amyotrophic lateral sclerosis continuum particularly in those with

Indexed as

AgedAmyotrophic Lateral SclerosisC9orf72 ProteinComorbidityFemaleFrontotemporal DementiaGray MatterHeterozygoteHumansMagnetic Resonance ImagingMaleMiddle AgedPsychotic DisordersRepetitive Sequences, Nucleic AcidC9orf72 ProteinC9orf72 protein, humanAmyotrophic lateral sclerosisC9orf72 expansionFrontotemporal dementiaNeuroimagingPsychosisSchizophrenia

Identifiers

PMID28116236
PMCPMC5233794
OpenAlexW2557746526

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.