ArticleNeuroImage. Clinical2017
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Ultra-High-Field MRI Morphometry of the Lateral Geniculate Nucleus in Patients with Advanced Visual Loss Due to Late-Stage Retinitis Pigmentosa.Brain sciences · 2026Article
- Noninvasive 11.7-T Magnetic Resonance Spectroscopy and Imaging Reveals Retinal Metabolic Alterations Induced by Blue Light Exposure.NMR in biomedicine · 2026Article
- Adaptive changes in the visual cortex after photoreceptor degeneration in retinitis pigmentosa.Histology and histopathology · 2025Review
- Cortical response to transient and long-term visual field loss.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Visual cortical thickness increases with prolonged artificial vision restoration.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Perceptual Visual Acuity Declines With Age in a Rat Model of Retinitis Pigmentosa While Light Perception is Maintained.Investigative ophthalmology & visual science · 2025Article
- Long term adult visual plasticity after the developmental critical period in genetically determinedHeliyon · 2025Article
- Good vision without peripheries: behavioral and fMRI evidence.Scientific reports · 2024Article
- Impact of macular scotoma and tubular vision on oculomotor behavior and performance in visuospatial comparison tasks.Journal of vision · 2024Article
- Deprivation of visual input alters specific subset of inhibitory neurons and affect thalamic afferent terminals in V1 ofFrontiers in cellular neuroscience · 2024Article
- Comparison of Stimulus Types for Retinotopic Cortical Mapping of Macular Disease.Translational vision science & technology · 2023Article
- Effects of nasal inflammation on the olfactory bulb.Journal of neuroinflammation · 2022Review
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Article
- Pathological consequences of chronic olfactory inflammation on neurite morphology of olfactory bulb projection neurons.Brain, behavior, & immunity - health · 2022Article
- Progressive Retinal Degeneration Increases Cortical Response Latency of Light Stimulation but Not of Electric Stimulation.Translational vision science & technology · 2022Article
- Cognitive dysfunctions in high myopia: An overview of potential neural morpho-functional mechanisms.Frontiers in neurology · 2022Review
- The detrimental effects of progression of retinal degeneration in the visual cortex.Frontiers in cellular neuroscience · 2022Review
- Opportunities to Discuss Diversity-Related Topics in Neuroscience Courses.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2022Article
- Structural evaluation in inherited retinal diseases.The British journal of ophthalmology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human studies addressing the long-term effects of peripheral retinal degeneration on visual cortical function and structure are scarce. Here we investigated this question in patients with Retinitis Pigmentosa (RP), a genetic condition leading to peripheral visual degeneration. We acquired functional and anatomical magnetic resonance data from thirteen patients with different levels of visual loss and twenty-two healthy participants to study primary (V1) visual cortical retinotopic remapping and cortical thickness. We identified systematic visual field remapping in the absence of structural changes in the primary visual cortex of RP patients. Remapping consisted in a retinotopic eccentricity shift of central retinal inputs to more peripheral locations in V1. Importantly, this was associated with changes in visual experience, as assessed by the extent of the visual loss, with more constricted visual fields resulting in larger remapping. This pattern of remapping is consistent with expansion or shifting of neuronal receptive fields into the cortical regions with reduced retinal input. These data provide evidence for functional changes in V1 that are dependent on the magnitude of peripheral visual loss in RP, which may be explained by rapid cortical adaptation mechanisms or long-term cortical reorganization. This study highlights the importance of analyzing the retinal determinants of brain functional and structural alterations for future visual restoration approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.