Evidence map›Paper›PMID 28116130›Full record

ArticleFuture science OA2016

Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion.

Mustafa A Kamani, Philippe Provençal, Michel Boutin, Natalia Pacienza, Xin Fan, Anton Novak, Tonny C Huang, Beth Binnington, Bryan C Au, Christiane Auray-Blais and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Mustafa A KamaniUniversity Health Network, Toronto, Ontario, M5G 1L7, Canada; University Health Network, Toronto, Ontario, M5G 1L7, Canada.
Philippe ProvençalDepartment of Pediatrics, Division of Medical Genetics, Université de Sherbrooke, CHUS, Hospital Fleurimont, Sherbrooke, Quebec, J1H 5N4, Canada; Department of Pediatrics, Division of Medical Genetics, Université de Sherbrooke, CHUS, Hospital Fleurimont, Sherbrooke, Quebec, J1H 5N4, Canada.
Michel BoutinDepartment of Pediatrics, Division of Medical Genetics, Université de Sherbrooke, CHUS, Hospital Fleurimont, Sherbrooke, Quebec, J1H 5N4, Canada; Department of Pediatrics, Division of Medical Genetics, Université de Sherbrooke, CHUS, Hospital Fleurimont, Sherbrooke, Quebec, J1H 5N4, Canada.
Natalia PacienzaUniversity Health Network, Toronto, Ontario, M5G 1L7, Canada; University Health Network, Toronto, Ontario, M5G 1L7, Canada.
Xin FanUniversity Health Network, Toronto, Ontario, M5G 1L7, Canada; University Health Network, Toronto, Ontario, M5G 1L7, Canada.
Anton NovakDivision of Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Division of Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.
Tonny C HuangUniversity Health Network, Toronto, Ontario, M5G 1L7, Canada; University Health Network, Toronto, Ontario, M5G 1L7, Canada.
Beth BinningtonDivision of Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Division of Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.
Bryan C AuUniversity Health Network, Toronto, Ontario, M5G 1L7, Canada; University Health Network, Toronto, Ontario, M5G 1L7, Canada.
Christiane Auray-BlaisDepartment of Pediatrics, Division of Medical Genetics, Université de Sherbrooke, CHUS, Hospital Fleurimont, Sherbrooke, Quebec, J1H 5N4, Canada; Department of Pediatrics, Division of Medical Genetics, Université de Sherbrooke, CHUS, Hospital Fleurimont, Sherbrooke, Quebec, J1H 5N4, Canada.
Clifford A LingwoodDivision of Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Departments of Biochemistry & Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Division of Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Departments of Biochemistry & Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Jeffrey A MedinUniversity Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; University Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
University Health Network · CAHospital for Sick Children · CAUniversité de Sherbrooke · CAHôpital Fleurimont · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimFabry disease is caused by α-galactosidase A deficiency leading to accumulation of globotriaosylceramide (Gb MATERIAL & METHODS/

resultsThorough characterization of the Fabry mouse sphingolipid profile by LC-MS revealed unique Gb

conclusionThese data provide insights into how specific sphingolipid species correlate with one another and how these correlations change in the α-galactosidase A-deficient state, potentially leading to the identification of more specific biomarkers of Fabry disease.

Indexed as

ceramideslipidomicslysosomal storage disorders

Identifiers

PMID28116130
PMCPMC5242178
OpenAlexW2531078734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.