Evidence map›Paper›PMID 28116035›Full record

ArticleOxidative medicine and cellular longevity2016

Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice.

S Falone, S Jr Santini, V Cordone, M Grannonico, M Cacchio, G Di Emidio, C Tatone, F Amicarelli

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. The effects of physical activity on female fertility: a narrative review.Journal of assisted reproduction and genetics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

S FaloneDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-5978-0545
S Jr SantiniDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0001-6577-5892
V CordoneDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
M GrannonicoDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
M CacchioDepartment of Biomedical Sciences, "G. d'Annunzio" University, Via dei Vestini, Chieti Scalo, Italy.
G Di EmidioDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0001-9442-6923
C TatoneDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-4978-2571
F AmicarelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy; Institute of Translational Pharmacology (IFT), National Research Council (CNR), L'Aquila, Italy.ORCID 0000-0003-4528-4660
University of L'Aquila · ITAlbert Einstein College of Medicine · USNational Academies of Sciences, Engineering, and Medicine · USUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Population aging results in urgent needs of interventions aimed at ensuring healthy senescence. Exercise often results in healthy aging, yet many molecular mechanisms underlying such effects still need to be identified. We here investigated whether the age-dependent accumulation of oxidative and methylglyoxal- (MG-) related molecular damage could be delayed by moderate exercise in the mouse ovary, an organ that first exhibits impaired function with advancing age in mammals. CD1 female mice underwent two- or four-month treadmill-based running through the transition from adult to middle age, when ovaries show signs of senescence, and markers of protection against reactive oxygen species (ROS) and MG were measured. The long-term exercise reduced the protein oxidative damage in the ovaries (

Indexed as

AgingAnimalsAntioxidantsCatalaseFemaleGlutathioneGlutathione PeroxidaseHydroxyacylglutathione HydrolaseLactoylglutathione LyaseMiceOrnithineOvaryOxidative StressPhysical Conditioning, AnimalProtein CarbonylationPyrimidinesAntioxidantsargpyrimidineCatalaseGlutathioneGlutathione PeroxidaseHydroxyacylglutathione HydrolaseLactoylglutathione LyaseOrnithinePyrimidinesPyruvaldehydeReactive Oxygen SpeciesSuperoxide DismutaseThiolester Hydrolases

Identifiers

PMID28116035
PMCPMC5225388
OpenAlexW2566061598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.