Trial reportMolecular psychiatry2018
A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.
Open access · hybridAbstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph
Trial report in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 11 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 11 pooled it
18.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 11 syntheses or guidelines pooled it, 216 citations in OpenAlex.
- Pooled it
- Increased somatic mosaicism in autosomal and X chromosomes for suicide death.Molecular psychiatry · 2025Pooled it
- A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse.Genes · 2022Pooled it
- Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Nature genetics · 2021Pooled it
- Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Pooled it
- Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.Nature communications · 2021Pooled it
- The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.Biological psychiatry · 2020Pooled it
- Genome-wide association study identifies 30 loci associated with bipolar disorder.Nature genetics · 2019Pooled it
- Multivariate analysis of genome-wide data to identify potential pleiotropic genes for five major psychiatric disorders using MetaCCA.Journal of affective disorders · 2019Pooled it
- Re-evaluating classical body type theories: genetic correlation between psychiatric disorders and body mass index.Psychological medicine · 2018Pooled it
- Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.Translational psychiatry · 2017Pooled it
- Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.JAMA psychiatry · 2018Trial
- Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.Research square · 2026Article
- Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.Molecular psychiatry · 2026Article
- Tractor workflow: a scalable Nextflow framework for local ancestry-aware genome-wide association studies.Bioinformatics (Oxford, England) · 2026Article
- Associations between mosaic loss and schizophrenia or bipolar disorder of young age.Molecular psychiatry · 2026Article
- Immune involvement in neuropsychiatric disorders: Insights from single-cell transcriptomic studies.Psychiatry and clinical neurosciences · 2026Review
- Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.Nature neuroscience · 2026Article
- Epigenetic Mechanisms of Suicidal Behavior Formation: A Review.Medical journal of the Islamic Republic of Iran · 2026Review
- Adolescent multi-omics and Mendelian randomization reveal transdiagnostic molecular mechanisms in psychiatric disorders.Nature. Mental health · 2026Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 20 institutions in 1 country.
M IkedaDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
A TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Y KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Y OkahisaDepartment of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
H KunugiDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
N MoriDepartment of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
T SasakiLaboratory of Health Education, Graduate School of Education, the University of Tokyo, Tokyo, Japan.
T OhmoriDepartment of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
Y OkamotoDepartment of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
H KawasakiDepartment of Psychiatry, Fukuoka University, Faculty of Medicine, Fukuoka, Japan.
S ShimoderaDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Japan.
T KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan.
H YonedaDepartment of Neuropsychiatry, Osaka Medical College, Takatsuki, Japan.
R YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyusyu, Japan.
M IyoDepartment of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
K MatsudaLaboratory of Clinical Sequence, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
M AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
K AshikawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Japan.
K KashiwaseJapanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
K TokunagaDepartment of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
K KondoDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
T SaitoDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
A ShimasakiDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
K KawaseDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
T KitajimaDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
K MatsuoDivision of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan.
M ItokawaCenter for Medical Cooperation, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
T SomeyaDepartment of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
T InadaDepartment of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Japan.
R HashimotoMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Japan.
T InoueDepartment of Psychiatry, Tokyo Medical University, Tokyo, Japan.
K AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.
H TaniiDepartment of Neuropsychiatry, Mie University, Graduate School of Medicine, Tsu, Japan.
H AraiDepartment of Psychiatry and Behavioral Sciences, Juntendo Graduate School of Medicine, Tokyo, Japan.
S KanbaDepartment of Neuropsychiatry, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan.
N OzakiDepartment of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Japan.
I KusumiDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
T YoshikawaLaboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan.
M KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
N IwataDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
Fujita Health University · JPChiba University · JPHamamatsu University School of Medicine · JPHiroshima University · JPHokkaido University · JPJapanese Red Cross Society, Japan · JPKyushu University · JPMie University · JPNagoya University · JPOkayama University · JPRIKEN Center for Brain Science · JPRIKEN Center for Integrative Medical Sciences · JPTokyo Medical University · JPFukuoka University · JPJapan Graduate School of Education University · JPNational Cerebral and Cardiovascular Center · JPOsaka Medical and Pharmaceutical University · JPTokyo Metropolitan Institute of Medical Science · JPUniversity of Occupational and Environmental Health Japan · JPYamaguchi University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In the present GWAS (Phase I/II), which included 2964 BD and 61 887 control subjects from the Japanese population, we detected a novel susceptibility locus at 11q12.2 (rs28456, P=6.4 × 10
Indexed as
AdultBipolar DisorderCell Cycle ProteinsCytokinesDelta-5 Fatty Acid DesaturaseFatty Acid DesaturasesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansJapanMaleMembrane GlycoproteinsMiddle AgedMultifactorial InheritanceNFI Transcription FactorsCell Cycle ProteinsCytokinesDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFADS2 protein, humanFatty Acid DesaturasesMAD1L1 protein, humanMembrane GlycoproteinsNFI Transcription FactorsNFIX protein, humanNuclear ProteinsTENM4 protein, humanTRANK1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.